Husnul F, Tirta C
Orthopaedic and Traumatology Department, Faculty of Medicine, Universitas Sumatera Utara/Haji Adam Malik General Hospital, Medan, Indonesia.
Orthopaedic and Traumatology Department, Faculty of Medicine, Universitas Sumatera Utara/Haji Adam Malik General Hospital, Medan, Indonesia.
Int J Surg Case Rep. 2024 Oct;123:110237. doi: 10.1016/j.ijscr.2024.110237. Epub 2024 Sep 6.
Tumor calcinosis is a rare and benign disorder characterized by calcified periarticular soft tissue masses. It may be idiopathic or caused by a condition known as hyperphosphatemia. There is still no definitive guideline for treating this disease, with excision being one of the primary treatment modalities.
2 patients with a history of longstanding diabetes and dialysis presented with a painless lump on their right buttock, measuring 18 × 30 cm in the right gluteal region. Laboratory examinations showed a high ureum, creatinine, and serum phosphate. A radiograph revealed opacity on the right hip joint, without involvement of the proximal femur bone. A biopsy confirmed the diagnosis of tumor calcinosis. Both patients were treated with calcium carbonate to control their high serum phosphate levels. Both patients showed excellent tumor control without progression.
Tumoral calcinosis (TC) is an extra-articular benign but aggressive tumor. The precise mechanism of TC remains unknown, which partly explains the lack of established treatment modality. We treat our patients with calcium carbonate to reduce the serum phosphate and treat the tumor without surgery. The treatment yielded a satisfactory clinical result.
This study showed that a secondary TC may be conservatively treated without any surgical excision if we address the underlying problem. But it may not result in a reduction of the tumor's size.
肿瘤性钙化是一种罕见的良性疾病，其特征为关节周围软组织肿块钙化。它可能是特发性的，也可能由高磷血症这种病症引起。目前对于这种疾病的治疗仍没有明确的指南，手术切除是主要的治疗方式之一。
2例有长期糖尿病和透析病史的患者，右侧臀部出现无痛性肿块，右侧臀区大小为18×30厘米。实验室检查显示尿素、肌酐和血清磷酸盐水平升高。X线片显示右髋关节有不透光区，近端股骨未受累。活检确诊为肿瘤性钙化。两名患者均接受碳酸钙治疗以控制其高血清磷酸盐水平。两名患者均显示出良好的肿瘤控制效果，无病情进展。
肿瘤性钙化（TC）是一种关节外的良性但侵袭性肿瘤。TC的确切机制尚不清楚，这在一定程度上解释了缺乏既定治疗方式的原因。我们用碳酸钙治疗患者以降低血清磷酸盐水平并在不进行手术的情况下治疗肿瘤。该治疗取得了令人满意的临床效果。
本研究表明，如果我们解决潜在问题，继发性TC可以不进行任何手术切除而进行保守治疗。但这可能不会导致肿瘤体积缩小。
