甲状腺激素对大鼠脂肪细胞膜中β-肾上腺素能受体数量的调节作用。
Thyroid-hormone modulation of the number of beta-adrenergic receptors in rat fat-cell membranes.
作者信息
Giudicelli Y
出版信息
Biochem J. 1978 Dec 15;176(3):1007-10. doi: 10.1042/bj1761007.
Abstract
Adipocytes from thyroidectomized rats contain 3 times less [3H]dihydroalprenolol-binding sites (beta-adrenergic receptors) than adipocytes from euthyroid animals. This alteration is not solely due to cell-size differences, but also to a thyroidectomy-induced defect in beta-adrenergic receptor density per adipocyte surface area, a defect that is furthermore corrected by tri-iodothyronine treatment.
摘要
甲状腺切除大鼠的脂肪细胞中[3H]二氢阿普洛尔结合位点（β-肾上腺素能受体）的数量比甲状腺功能正常动物的脂肪细胞少3倍。这种改变不仅是由于细胞大小的差异，还归因于甲状腺切除引起的每个脂肪细胞表面积β-肾上腺素能受体密度的缺陷，而且这种缺陷可通过三碘甲状腺原氨酸治疗得到纠正。
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