Vascular Biology and Atherosclerosis Research Laboratory, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Eur J Vasc Endovasc Surg. 2011 Sep;42 Suppl 1:S19-29. doi: 10.1016/j.ejvs.2011.06.013.
Vein bypass grafting is an integral component of cardiovascular surgical practice for both arterial and venous diseases. However, many of these grafts will eventually fail due to either intrinsic or extrinsic causes. This review examines the current understanding and knowledge of venous histology, vein graft pathology and the associated endothelial and smooth muscle cell physiology and pharmacology. In addition, the status of research on the therapeutic control of vein graft intimal hyperplasia and accelerated atherosclerosis is assessed.
静脉旁路移植术是心血管外科治疗动静脉疾病的一个重要组成部分。然而，由于内在或外在的原因，这些移植物中的许多最终都会失效。本综述检查了静脉组织学、静脉移植物病理学以及相关的内皮和平滑肌细胞生理学和药理学的现有理解和知识。此外，还评估了关于静脉移植内膜增生和加速动脉粥样硬化的治疗控制的研究现状。
