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Body surface area-based dosing of 5-fluoruracil results in extensive interindividual variability in 5-fluorouracil exposure in colorectal cancer patients on FOLFOX regimens.

作者信息

Saam Jennifer, Critchfield Gregory C, Hamilton Stephanie A, Roa Benjamin B, Wenstrup Richard J, Kaldate Rajesh R

机构信息

Myriad Genetic Laboratories, Inc, Salt Lake City, UT, USA.

出版信息

Clin Colorectal Cancer. 2011 Sep;10(3):203-6. doi: 10.1016/j.clcc.2011.03.015. Epub 2011 Apr 28.

DOI:10.1016/j.clcc.2011.03.015
PMID:21855044
Abstract
摘要

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Pharmacogenomic-guided dosing of fluoropyrimidines beyond : time for a polygenic algorithm?氟嘧啶基于药物基因组学的给药之外:是时候采用多基因算法了吗?
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