Escola Nacional de Saude Publica / Fundação Osvaldo Cruz, Rio de Janeiro, Brazil.
Trans R Soc Trop Med Hyg. 2011 Oct;105(10):601-3. doi: 10.1016/j.trstmh.2011.07.007. Epub 2011 Aug 19.
During a dengue epidemic in Rio de Janeiro in 2007-2008 the Instituto de Puericultura e Pediatria Martagão Gesteira Hospital was a reference for admitted children. The World Health Organization (WHO) considered several manifestations as warning signs of severe dengue This is a retrospective cohort study of all children admitted with dengue fever. Clinical variables considered warning signs by WHO were evaluated in the multivariate analysis, to investigate if they were independently associated with severe dengue. One hundred and eighty one children were admitted, aged from 4 months to 15 years; 30 were classified as severe dengue. Abdominal pain (OR=2.63, 95% CI 1.06-6.53) and lethargy (OR=3.40, 95% CI 1.45-7.99) were independently associated with severe dengue.
2007-2008 年里约热内卢登革热流行期间，Martagão Gesteira 儿科研究所医院成为收治患儿的定点医院。世界卫生组织（WHO）认为，一些表现为重症登革热的预警信号。本研究是一项对所有患有登革热住院患儿的回顾性队列研究。对 WHO 认为的临床预警信号进行多变量分析，以调查它们是否与重症登革热独立相关。共收治 181 名年龄在 4 个月至 15 岁的患儿，其中 30 名患儿被诊断为重症登革热。腹痛（OR=2.63，95%CI 1.06-6.53）和嗜睡（OR=3.40，95%CI 1.45-7.99）与重症登革热独立相关。
