Duzce University Medical Faculty, Department of Emergency Medicine, Duzce, Turkey.
Am J Emerg Med. 2012 Sep;30(7):1321.e3-4. doi: 10.1016/j.ajem.2011.05.032. Epub 2011 Aug 19.
The incidence of ceftriaxone-related hypersensitivity skin reactions is between 1% and 3%, whereas anaphylaxis is rare. To the best of our knowledge, the following case is the first report of asystole after the administration of single-dose ceftriaxone. A 55-year-old man was admitted to our emergency department because of high fever, abdominal pain, dysuria, and weakness. To determine the cause of his fever, blood and urine cultures were obtained. Then, an infusion of 1 g ceftriaxone was started slowly. One minute later, cardiac arrest occurred. The rhythm was asystole. Cardiopulmonary resuscitation and tracheal intubation were performed immediately, and the ceftriaxone infusion was discontinued. Within 20 minutes, circulation was restored. The time of onset was suggestive of ceftriaxone-induced anaphylaxis. The patient was discharged in good clinical condition on the 10th day of admission. Emergency physicians should be mindful of the possibility of anaphylaxis and asystole that could occur with the first dose of ceftriaxone and should also make sure to offer receiving detailed informed patient consent, too.
头孢曲松相关性过敏皮肤反应的发生率为 1%至 3%，而过敏反应则较为罕见。据我们所知，以下病例是首例单次头孢曲松给药后发生心搏停止的报告。一名 55 岁男性因高热、腹痛、尿痛和乏力而被收入我院急诊科。为确定发热原因，采集了血和尿培养。然后，开始缓慢输注 1 g 头孢曲松。1 分钟后，发生心脏骤停。节律为心搏停止。立即进行心肺复苏和气管插管，并停止输注头孢曲松。20 分钟内恢复循环。发病时间提示头孢曲松引起的过敏反应。患者在入院第 10 天临床状况良好出院。急诊医生应注意到首次使用头孢曲松可能发生过敏反应和心搏停止的可能性，并且还应确保获得详细的知情患者同意。
