Department of Bioenvironmental Systems Engineering, National Taiwan University, No. 1 Roosevelt Road, Sec. 4, Taipei 106, Taiwan.
Mech Ageing Dev. 2011 Oct;132(10):480-7. doi: 10.1016/j.mad.2011.07.008. Epub 2011 Aug 9.
Curcumin is the active ingredient in the herbal medicine and dietary spice, turmeric (Curcuma longa). It has a wide range of biological activities, including anti-inflammatory, antioxidant, chemopreventive, and chemotherapeutic activities. We examined the effects of curcumin on the lifespan and aging in Caenorhabditis elegans, and found that it responded to curcumin with an increased lifespan and reduced intracellular reactive oxygen species and lipofuscin during aging. We analyzed factors that might influence lifespan extension by curcumin. We showed that lifespan extension by curcumin in C. elegans is attributed to its antioxidative properties but not its antimicrobial properties. Moreover, we showed that lifespan extension had effects on body size and the pharyngeal pumping rate but not on reproduction. Finally, lifespan tests with selected stress- and lifespan-relevant mutant strains revealed that the lifespan-extending phenotype was absent from the osr-1, sek-1, mek-1, skn-1, unc-43, sir-2.1, and age-1 mutants, whereas curcumin treatment prolonged the lifespan of mev-1 and daf-16 mutants. Our study has unraveled a diversity of modes of action and signaling pathways to longevity and aging with curcumin exposure in vivo.
姜黄素是草药和膳食香料姜黄（Curcuma longa）中的活性成分。它具有广泛的生物学活性，包括抗炎、抗氧化、化学预防和化疗活性。我们研究了姜黄素对秀丽隐杆线虫寿命和衰老的影响，发现它对姜黄素的反应是寿命延长，衰老过程中细胞内活性氧和脂褐素减少。我们分析了可能影响姜黄素延长寿命的因素。我们表明，姜黄素在秀丽隐杆线虫中延长寿命归因于其抗氧化特性，而不是其抗菌特性。此外，我们表明，寿命延长对体型和咽部抽吸率有影响，但对繁殖没有影响。最后，对选定的应激和寿命相关突变株的寿命测试表明，osr-1、sek-1、mek-1、skn-1、unc-43、sir-2.1 和 age-1 突变株中没有延长寿命的表型，而姜黄素处理延长了 mev-1 和 daf-16 突变株的寿命。我们的研究揭示了姜黄素暴露在体内对长寿和衰老的多种作用方式和信号通路。
