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精神分裂症患者常伴有失眠,且与夜间进食和肥胖有关。

Insomnia is frequent in schizophrenia and associated with night eating and obesity.

机构信息

Department of Psychiatry, Yale University School of Medicine, 34 Park St Room 10, New Haven, CT 06519, United States.

出版信息

Schizophr Res. 2011 Dec;133(1-3):238-43. doi: 10.1016/j.schres.2011.07.030.

Abstract

BACKGROUND

Sleep difficulties are common in schizophrenia, however these complaints are often overshadowed by more prominent clinical concerns. The point prevalence of insomnia in this population is not well documented. Poor sleep is associated with lower quality of life, impaired cognition, and weight gain.

OBJECTIVES

The objectives of this study are to evaluate the prevalence of insomnia in schizophrenia and to explore the relationship of sleep to cognition, quality of life, and clinical variables.

METHOD

175 outpatients with schizophrenia or schizoaffective disorder were assessed for insomnia. Participants were evaluated for sleep difficulties, sleep patterns, body mass index, and psychiatric symptoms. Participants were also administered a brief cognitive assessment of processing speed.

RESULTS

44% of the sample currently met the criteria for clinical insomnia. An additional 4% were successfully treated with medications. Insomnia was associated with depression and was an independent predictor of lower quality of life. Insomnia was also associated with high rates of night eating and patients with severe insomnia were significantly more obese. The type of antipsychotic did not account for the difference in body mass index. No difference between group means in cognition was detected, although those with severe insomnia did perform least well.

CONCLUSION

Clinical insomnia in outpatients with schizophrenia is highly prevalent and has a negative impact on quality of life and psychiatric symptoms. This study offers additional support to the association between poor sleep and higher weight, as well as indicating a potential link to night eating in this population. Assessment for sleep difficulties should be a routine part of clinical care.

摘要

背景

睡眠困难在精神分裂症中很常见,但这些抱怨往往被更突出的临床问题所掩盖。该人群中失眠的时点患病率尚未得到充分记录。睡眠质量差与生活质量下降、认知功能受损和体重增加有关。

目的

本研究旨在评估精神分裂症患者中失眠的患病率,并探讨睡眠与认知、生活质量和临床变量的关系。

方法

对 175 名精神分裂症或分裂情感障碍的门诊患者进行失眠评估。评估了参与者的睡眠困难、睡眠模式、体重指数和精神症状。还对参与者进行了简短的认知处理速度评估。

结果

该样本中 44%目前符合临床失眠标准。另有 4%的患者成功接受了药物治疗。失眠与抑郁有关,是生活质量下降的独立预测因素。失眠还与夜间进食率高有关,严重失眠的患者明显更肥胖。抗精神病药物的类型并不能解释体重指数的差异。虽然认知方面两组间的均值没有差异,但严重失眠的患者表现最差。

结论

精神分裂症门诊患者的临床失眠症患病率很高,对生活质量和精神症状有负面影响。本研究进一步证实了睡眠质量差与体重增加之间的关联,并表明在该人群中睡眠质量差与夜间进食之间存在潜在联系。对睡眠困难的评估应成为临床护理的常规内容。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd5/5581545/60329384227f/nihms437789f1.jpg

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