Department of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Cancer Res. 2011 Oct 1;71(19):6116-21. doi: 10.1158/0008-5472.CAN-10-4557. Epub 2011 Aug 19.
Advancements in nanotechnology have made it possible to create multifunctional nanostructures that can be used simultaneously to image and treat cancers. For example, hollow gold nanospheres (HAuNS) have been shown to generate intense photoacoustic signals and induce efficient photothermal ablation (PTA) therapy. In this study, we used photoacoustic tomography, a hybrid imaging modality, to assess the intravenous delivery of HAuNS targeted to integrins that are overexpressed in both glioma and angiogenic blood vessels in a mouse model of glioma. Mice were then treated with near-infrared laser, which elevated tumor temperature by 20.7°C. We found that PTA treatment significantly prolonged the survival of tumor-bearing mice. Taken together, these results show the feasibility of using a single nanostructure for image-guided local tumor PTA therapy with photoacoustic molecular imaging.
纳米技术的进步使得创建多功能纳米结构成为可能，这些结构可以同时用于癌症成像和治疗。例如，空心金纳米球（HAuNS）已被证明可以产生强烈的光声信号，并诱导有效的光热消融（PTA）治疗。在这项研究中，我们使用光声断层扫描术，一种混合成像方式，来评估靶向整合素的 HAuNS 的静脉内递送，整合素在胶质瘤和血管生成血管中过度表达，在胶质瘤的小鼠模型中。然后，用近红外激光对小鼠进行治疗，使肿瘤温度升高 20.7°C。我们发现 PTA 治疗显著延长了荷瘤小鼠的存活时间。总之，这些结果表明，使用单个纳米结构进行光声分子成像引导的局部肿瘤 PTA 治疗是可行的。
