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用于胶质瘤治疗的时空可控系统的最新进展

Recent advances in spatio-temporally controllable systems for management of glioma.

作者信息

Zhang Huiwen, Zhu Wanqi, Pan Wei, Wan Xiuyan, Li Na, Tang Bo

机构信息

College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, China.

Laoshan Laboratory, Qingdao 266237, China.

出版信息

Asian J Pharm Sci. 2024 Oct;19(5):100954. doi: 10.1016/j.ajps.2024.100954. Epub 2024 Aug 22.

DOI:10.1016/j.ajps.2024.100954
PMID:39483717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11525460/
Abstract

Malignant glioma remains one of the most aggressive intracranial tumors with devastating clinical outcomes despite the great advances in conventional treatment approaches, including surgery and chemotherapy. Spatio-temporally controllable approaches to glioma are now being actively investigated due to the preponderance, including spatio-temporal adjustability, minimally invasive, repetitive properties, etc. External stimuli can be readily controlled by adjusting the site and density of stimuli to exert the cytotoxic on glioma tissue and avoid undesired injury to normal tissues. It is worth noting that the removability of external stimuli allows for on-demand treatment, which effectively reduces the occurrence of side effects. In this review, we highlight recent advancements in drug delivery systems for spatio-temporally controllable treatments of glioma, focusing on the mechanisms and design principles of sensitizers utilized in these controllable therapies. Moreover, the potential challenges regarding spatio-temporally controllable therapy for glioma are also described, aiming to provide insights into future advancements in this field and their potential clinical applications.

摘要

尽管包括手术和化疗在内的传统治疗方法取得了巨大进展，但恶性胶质瘤仍然是最具侵袭性的颅内肿瘤之一，临床预后不佳。由于具有时空可调性、微创性、可重复性等优势，目前正在积极研究针对胶质瘤的时空可控治疗方法。通过调整刺激的部位和密度，可以很容易地控制外部刺激，从而对胶质瘤组织发挥细胞毒性作用，同时避免对正常组织造成不必要的损伤。值得注意的是，外部刺激的可去除性允许按需治疗，这有效地减少了副作用的发生。在这篇综述中，我们重点介绍了用于胶质瘤时空可控治疗的药物递送系统的最新进展，重点关注这些可控治疗中使用的敏化剂的作用机制和设计原则。此外，还描述了胶质瘤时空可控治疗面临的潜在挑战，旨在为该领域的未来进展及其潜在的临床应用提供见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/76c38430444c/gr12.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/f8e3b4b1fb1d/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/76c38430444c/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/05571ddb59d0/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/d818fdd7580e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/da380e971d11/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/96369f890fa7/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/74536538f539/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/5043a70e0370/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/031256cf8f33/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/6d05256d7ffd/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/0af75be28573/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/d42daec84961/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/13070d066061/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/f8e3b4b1fb1d/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc25/11525460/76c38430444c/gr12.jpg

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