醋酸钙不动杆菌无硝亚种临床分离株对环丙沙星及其他抗菌药物的交叉耐药性。
Cross resistance to ciprofloxacin and other antimicrobial agents among clinical isolates of Acinetobacter calcoaceticus biovar anitratus.
作者信息
Shalit I, Dan M, Gutman R, Gorea A, Berger S A
机构信息
Infectious Disease Division, Tel-Aviv Medical Center, Israel.
出版信息
Antimicrob Agents Chemother. 1990 Mar;34(3):494-5. doi: 10.1128/AAC.34.3.494.
Abstract
Using an agar dilution assay, for 66 of 104 (63.5%) clinical isolates of Acinetobacter calcoaceticus biovar anitratus, the MIC of ciprofloxacin was greater than or equal to 1.0 micrograms/ml. Cross resistance was demonstrable to ciprofloxacin and gentamicin (P less than 0.001), amikacin (P less than 0.01), cefotaxime (P less than 0.001), azlocillin (P less than 0.001), ceftazidime (P less than 0.001), trimethoprim-sulfamethoxazole (P less than 0.001), and minocycline (P less than 0.05). The mean MIC of ciprofloxacin for drug-susceptible isolates was consistently lower than that for resistant isolates; however, these differences were significant only for amikacin (P = 0.036).
摘要
采用琼脂稀释法检测，在104株醋酸钙不动杆菌无硝亚种临床分离株中，有66株（63.5%）对环丙沙星的最低抑菌浓度（MIC）大于或等于1.0微克/毫升。对环丙沙星与庆大霉素（P<0.001）、阿米卡星（P<0.01）、头孢噻肟（P<0.001）、阿洛西林（P<0.001）、头孢他啶（P<0.001）、甲氧苄啶-磺胺甲恶唑（P<0.001）和米诺环素（P<0.05）可显示交叉耐药。药物敏感分离株的环丙沙星平均MIC始终低于耐药分离株；然而，这些差异仅对阿米卡星有统计学意义（P = 0.036）。
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