庆大霉素耐药和敏感的“鲍曼不动杆菌”对15种替代抗生素的敏感性比较。
Comparison of susceptibility of gentamicin-resistant and -susceptible "Acinetobacter anitratus" to 15 alternative antibiotics.
作者信息
Stiver H G, Bartlett K H, Chow A W
出版信息
Antimicrob Agents Chemother. 1986 Oct;30(4):624-5. doi: 10.1128/AAC.30.4.624.
Abstract
Fifty-four clinical isolates of "Acinetobacter anitratus" separated cleanly into gentamicin-susceptible (16 strains) and gentamicin-resistant (38 strains) subpopulations. When tested with a 10(4)-CFU inoculum, gentamicin resistance was associated with a greater than fourfold increase in the MICs of norfloxacin, ciprofloxacin, A-56620, tobramycin, and amikacin for 50% of the strains. Antimicrobial agents with MICs for 90% of gentamicin-resistant strains in the susceptible range were ciprofloxacin, A-56619, A-56620, imipenem, SCH-34343, ceftazidime, aztreonam, carbenicillin, ticarcillin, and piperacillin. These agents may be useful alternative drugs for treating infections caused by aminoglycoside-susceptible and -resistant "A. anitratus."
摘要
54株“无硝不动杆菌”临床分离株可清晰地分为对庆大霉素敏感（16株）和耐药（38株）两个亚群。当用10⁴CFU接种量进行测试时，50%的菌株对庆大霉素耐药与诺氟沙星、环丙沙星、A - 56620、妥布霉素和阿米卡星的最低抑菌浓度（MIC）增加四倍以上相关。对于90%庆大霉素耐药菌株，MIC处于敏感范围的抗菌药物有环丙沙星、A - 56619、A - 56620、亚胺培南、SCH - 34343、头孢他啶、氨曲南、羧苄西林、替卡西林和哌拉西林。这些药物可能是治疗由对氨基糖苷类敏感和耐药的“无硝不动杆菌”引起感染的有用替代药物。
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