Stagnaro-Green Alex
George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Clin Obstet Gynecol. 2011 Sep;54(3):478-87. doi: 10.1097/GRF.0b013e3182272f32.
The present manuscript provides a definition for, and evaluates the prevalence and maternal/fetal/child impact of, overt hyperthyroidism and overt hypothyroidism. The prevalence of overt hyperthyroidism is 0.5% and the prevalence of overt hyperthyroidism is 0.3%. Overt maternal hyperthyroidism is associated with heart failure, preeclampsia, preterm delivery, still birth, and neonatal mortality. Overt maternal hypothyroidism is associated with preeclampsia, gestational hypertension, cretinism, fetal deaths, and spontaneous abortion. A cost-effective analysis for screening and treating overt thyroid disease during pregnancy is warranted.
本手稿给出了显性甲状腺功能亢进症和显性甲状腺功能减退症的定义，并评估了其患病率以及对母婴/儿童的影响。显性甲状腺功能亢进症的患病率为0.5%，显性甲状腺功能减退症的患病率为0.3%。孕妇显性甲状腺功能亢进症与心力衰竭、先兆子痫、早产、死产及新生儿死亡有关。孕妇显性甲状腺功能减退症与先兆子痫、妊娠高血压、呆小病、胎儿死亡及自然流产有关。有必要对孕期显性甲状腺疾病的筛查和治疗进行成本效益分析。
