免疫球蛋白 A 抗麦胶蛋白抗体有助于诊断 2 岁以下儿童的乳糜泻吗？
Are immunoglobulin A anti-gliadin antibodies helpful in diagnosing coeliac disease in children younger than 2 years?
机构信息
Department of Immunology, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Inserm U851, Pierre-Benite, France.
出版信息
J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):110-2. doi: 10.1097/MPG.0b013e31823255c9.
The usefulness of immumoglobulin (Ig) A antibodies to gliadin (AGA-IgA) in addition to IgA anti-endomysium and tissue transglutaminase antibodies was evaluated in 4122 children younger than 2 years with a suspicion of coeliac disease (CD). Eight percent (312/4122) displayed IgA anti-endomysium and/or IgA anti-tissue transglutaminase, whereas 2.1% (85/4122) displayed only AGA-IgA. Clinical data were obtained for 62 of 85 children with isolated AGA-IgA, and 33 children underwent a duodenal biopsy. Histologically proven CD was established for 5 patients, whereas 57 children were diagnosed to experience other diseases. The systematic detection of AGA-IgA using native gliadin conferred no additional diagnostic benefit for the diagnosis of CD in children younger than 2 years of age, except for rare cases.
在 4122 名疑似乳糜泻（CD）的 2 岁以下儿童中，评估了免疫球蛋白（Ig）A 抗麦胶蛋白（AGA-IgA）除 IgA 抗内肌膜和组织转谷氨酰胺酶抗体以外的其他作用。8%（312/4122）显示出 IgA 抗内肌膜和/或 IgA 抗组织转谷氨酰胺酶，而 2.1%（85/4122）仅显示 AGA-IgA。对 85 名仅显示 AGA-IgA 的儿童中的 62 名进行了临床数据采集，并且 33 名儿童接受了十二指肠活检。组织学证实 CD 为 5 例，而 57 例儿童被诊断为患有其他疾病。除了罕见病例，使用天然麦胶蛋白进行 AGA-IgA 的系统检测对于 2 岁以下儿童 CD 的诊断并没有提供额外的诊断益处。
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