Clinical Research, NeuroResearch Clinics, Inc, Cape Coral, FL, USA;
Neuropsychiatr Dis Treat. 2011;7:457-63. doi: 10.2147/IJN.S22667. Epub 2011 Aug 5.
THE MONOAMINES SEROTONIN AND DOPAMINE ARE KNOWN TO EXIST IN TWO SEPARATE STATES: the endogenous state and the competitive inhibition state. The presence of the competitive inhibition state has been known to science for many years, but from a functional standpoint it has been noted in the literature as being "meaningless."
A large database of monoamine transporter response to amino acid precursor administration variations with clinical outcomes was accumulated. In the process, a new organic cation transporter (OCT) model has been published, and OCT functional status determination along with amino acid precursor manipulation methods have been invented and refined.
Methodology was developed whereby manipulation of the OCT, in the competitive inhibition state, is carried out in a predictable manner. This, in turn, has disproved the long-held assertion that the monoamine competitive inhibition state is functionally meaningless.
The most significant aspect of this paper is the documentation of newly recognized relationships between serotonin and dopamine. When transport of serotonin and dopamine are both in the competitive inhibition state, manipulation of the concentrations of one will lead to predictable changes in concentrations of the other. From a functional standpoint, processes regulated and controlled by changes to only serotonin can now be controlled by changes to dopamine, and vice versa, in a predictable manner.
众所周知，单胺类物质血清素和多巴胺存在于两种不同的状态：内源性状态和竞争性抑制状态。多年来，科学界已经知道存在竞争性抑制状态，但从功能角度来看，文献中一直将其描述为“毫无意义”。
积累了大量关于单胺转运体对氨基酸前体给药变化与临床结果的反应的大型数据库。在此过程中，已经发表了一种新的有机阳离子转运体（OCT）模型，并发明和完善了 OCT 功能状态确定以及氨基酸前体操作方法。
开发了一种方法，通过该方法，可以以可预测的方式对 OCT 的竞争性抑制状态进行操作。这反过来又证明了长期以来一直认为单胺竞争性抑制状态在功能上毫无意义的观点是错误的。
本文最重要的方面是记录了新发现的血清素和多巴胺之间的关系。当血清素和多巴胺的转运都处于竞争性抑制状态时，对一种物质浓度的操作将导致另一种物质浓度的可预测变化。从功能角度来看，现在可以通过改变多巴胺来控制仅由血清素调节和控制的过程，反之亦然，并且可以以可预测的方式进行。
