预防性治疗对活动性肾结石患者长期肾功能的影响。

The impact of metaphylaxis of kidney stone disease in the renal function at long term in active kidney stone formers patients.

作者信息

Meneses Jose A, Lucas Fernando M, Assunção Fernando C, Castro Junia P P, Monteiro Rogério B

机构信息

Nephrologist of Clinic Stone Lithocentro, Belo Horizonte, Brazil.

出版信息

Urol Res. 2012 Jun;40(3):225-9. doi: 10.1007/s00240-011-0407-5. Epub 2011 Aug 20.

DOI:10.1007/s00240-011-0407-5

PMID:21858428

Abstract

A total of 150 patients were included in the analysis. Through chart review, we estimated glomerular filtration rate in the first visit and, at least, 5 years later. All patients were divided into two groups: (1) metaphylaxis adherents (n = 74) and (2) metaphylaxis non-adherents (n = 76). We followed all patients for at least 5 years. The Scr percentage of patients and GFR <60 mL/min was compared between groups. Variables were compared between groups using t test, χ(2) tests, odds ratios with 95% confidence intervals. There were no differences at baseline between groups. After 5 years of follow-up, GFR was 77.9 mL/min in non-adherent-metaphylaxis group and in the adherent-metaphylaxis group was 87.3 mL/min, with p value of 0.02. After 5 years of follow-up, we had a GFR <60 mL/min in the adherent-metaphylaxis group (4.89 vs. 21.95%) with p value of 0.001 and OR = 5.36; IC-95% = 1.95-14.8. Metaphylaxis of kidney stone disease could prevent chronic kidney disease.

摘要

共有150例患者纳入分析。通过查阅病历，我们估算了首次就诊时以及至少5年后的肾小球滤过率。所有患者分为两组：（1）预防依从组（n = 74）和（2）预防不依从组（n = 76）。我们对所有患者随访至少5年。比较了两组患者的Scr百分比以及肾小球滤过率<60 mL/分钟的情况。组间变量比较采用t检验、χ²检验、95%置信区间的比值比。两组在基线时无差异。随访5年后，预防不依从组的肾小球滤过率为77.9 mL/分钟，预防依从组为87.3 mL/分钟，p值为0.02。随访5年后，预防依从组肾小球滤过率<60 mL/分钟的比例为4.89%，而预防不依从组为21.95%，p值为0.001，比值比=5.36；95%置信区间为1.95 - 14.8。肾结石病的预防可预防慢性肾脏病。