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Gemcitabine, fludarabine and melphalan as a reduced-intensity conditioning regimen for allogeneic stem cell transplant in relapsed and refractory Hodgkin lymphoma: preliminary results.吉西他滨、氟达拉滨和美法仑作为复发难治性霍奇金淋巴瘤异基因干细胞移植的减低强度预处理方案：初步结果
Leuk Lymphoma. 2012 Mar;53(3):499-502. doi: 10.3109/10428194.2011.615427. Epub 2011 Oct 24.
2
Gemcitabine, Fludarabine, and Melphalan for Reduced-Intensity Conditioning and Allogeneic Stem Cell Transplantation for Relapsed and Refractory Hodgkin Lymphoma.吉西他滨、氟达拉滨和美法仑用于复发难治性霍奇金淋巴瘤的减低剂量预处理及异基因干细胞移植
Biol Blood Marrow Transplant. 2016 Jul;22(7):1333-1337. doi: 10.1016/j.bbmt.2016.03.028. Epub 2016 Apr 6.
3
High-dose chemotherapy in relapsed or refractory Hodgkin lymphoma patients: a reappraisal of prognostic factors.复发或难治性霍奇金淋巴瘤患者的大剂量化疗：预后因素的再评价。
Hematol Oncol. 2013 Mar;31(1):34-40. doi: 10.1002/hon.2014. Epub 2012 Mar 30.
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Long-term outcomes after reduced-intensity conditioning allogeneic stem cell transplantation for low-grade lymphoma: a survey by the French Society of Bone Marrow Graft Transplantation and Cellular Therapy (SFGM-TC).低级别淋巴瘤减强度预处理异基因干细胞移植后的长期疗效：法国骨髓移植与细胞治疗协会（SFGM-TC）的一项调查
Haematologica. 2007 May;92(5):627-34. doi: 10.3324/haematol.10924.
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Phase II Study of Yttrium-90-Ibritumomab Tiuxetan as Part of Reduced-Intensity Conditioning (with Melphalan, Fludarabine ± Thiotepa) for Allogeneic Transplantation in Relapsed or Refractory Aggressive B Cell Lymphoma: A GELTAMO Trial.钇-90 替伊莫单抗作为减低强度预处理（联合美法仑、氟达拉滨±噻替派）用于复发或难治性侵袭性 B 细胞淋巴瘤异基因移植的 II 期研究：一项 GELTAMO 试验
Biol Blood Marrow Transplant. 2017 Jan;23(1):53-59. doi: 10.1016/j.bbmt.2016.10.003. Epub 2016 Oct 19.
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Fludarabine and melphalan-based conditioning for patients with advanced hematological malignancies relapsing after a previous hematopoietic stem cell transplant.对于先前造血干细胞移植后复发的晚期血液系统恶性肿瘤患者，采用氟达拉滨和美法仑进行预处理。
Bone Marrow Transplant. 2001 Sep;28(6):557-62. doi: 10.1038/sj.bmt.1703198.
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Reduced toxicity conditioning and allogeneic stem cell transplantation in adults using fludarabine, carmustine, melphalan, and antithymocyte globulin: outcomes depend on disease risk index but not age, comorbidity score, donor type, or human leukocyte antigen mismatch.氟达拉滨、卡莫司汀、马法兰和抗胸腺细胞球蛋白用于成人降低毒性预处理和同种异体干细胞移植：结果取决于疾病风险指数，但与年龄、合并症评分、供体类型或人类白细胞抗原错配无关。
Biol Blood Marrow Transplant. 2013 Aug;19(8):1167-74. doi: 10.1016/j.bbmt.2013.05.001. Epub 2013 May 7.
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Late relapses following reduced intensity allogeneic transplantation in patients with multiple myeloma: a long-term follow-up study.多发性骨髓瘤患者接受减低强度异基因移植后的晚期复发：一项长期随访研究。
Br J Haematol. 2013 Jan;160(2):199-206. doi: 10.1111/bjh.12123. Epub 2012 Nov 15.
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Rapid induction of complete donor chimerism by the use of a reduced-intensity conditioning regimen composed of fludarabine and melphalan in allogeneic stem cell transplantation for metastatic solid tumors.在转移性实体瘤的异基因干细胞移植中，使用由氟达拉滨和美法仑组成的低强度预处理方案快速诱导完全供体嵌合状态。
Blood. 2003 Nov 15;102(10):3829-36. doi: 10.1182/blood-2003-04-1022. Epub 2003 Jul 24.
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Allogeneic stem cell transplantation using lymphoablative rather than myeloablative conditioning regimen for relapsed or refractory lymphomas.使用淋巴细胞清除而非骨髓清除预处理方案进行异基因干细胞移植治疗复发或难治性淋巴瘤。
Hematol Oncol. 2017 Mar;35(1):17-24. doi: 10.1002/hon.2201. Epub 2015 Mar 18.

引用本文的文献

1
Allogeneic hematopoietic stem cell transplantation in Hodgkin lymphoma: a systematic review and meta-analysis.霍奇金淋巴瘤的异基因造血干细胞移植：一项系统评价和荟萃分析。
Bone Marrow Transplant. 2016 Apr;51(4):521-8. doi: 10.1038/bmt.2015.332. Epub 2016 Jan 4.
2
Mechanistic studies on the synergistic cytotoxicity of the nucleoside analogs gemcitabine and clofarabine in multiple myeloma: relevance of p53 and its clinical implications.机制研究核苷类似物吉西他滨和克拉屈滨在多发性骨髓瘤中的协同细胞毒性作用：p53 的相关性及其临床意义。
Exp Hematol. 2013 Aug;41(8):719-30. doi: 10.1016/j.exphem.2013.04.009. Epub 2013 May 3.

本文引用的文献

1
Doxorubicin, vinblastine, and gemcitabine (CALGB 50203) for stage I/II nonbulky Hodgkin lymphoma: pretreatment prognostic factors and interim PET.多柔比星、长春碱和吉西他滨（CALGB 50203）治疗 I/II 期非肿块性霍奇金淋巴瘤：预处理预后因素和中期 PET。
Blood. 2011 May 19;117(20):5314-20. doi: 10.1182/blood-2010-10-314260. Epub 2011 Feb 25.
2
Phase I/II trial of GN-BVC, a gemcitabine and vinorelbine-containing conditioning regimen for autologous hematopoietic cell transplantation in recurrent and refractory hodgkin lymphoma.复发难治性霍奇金淋巴瘤患者采用含吉西他滨和长春瑞滨的 GN-BVC 方案进行自体造血细胞移植的 I/II 期临床试验。
Biol Blood Marrow Transplant. 2010 Aug;16(8):1145-54. doi: 10.1016/j.bbmt.2010.02.022. Epub 2010 Mar 1.
3
Reduced intensity conditioning allogeneic stem cell transplantation for Hodgkin's lymphoma: identification of prognostic factors predicting outcome.减低预处理强度异基因干细胞移植治疗霍奇金淋巴瘤：预测预后的预后因素识别
Haematologica. 2009 Feb;94(2):230-8. doi: 10.3324/haematol.13441. Epub 2008 Dec 9.
4
Allogeneic transplantation for Hodgkin lymphoma.霍奇金淋巴瘤的异基因移植
Br J Haematol. 2008 Nov;143(4):468-80. doi: 10.1111/j.1365-2141.2008.07349.x. Epub 2008 Aug 15.
5
Current role of gemcitabine in the treatment of Hodgkin lymphoma.吉西他滨在霍奇金淋巴瘤治疗中的当前作用。
Leuk Lymphoma. 2008 May;49(5):883-9. doi: 10.1080/10428190801911704.
6
Allo-SCT using reduced-intensity conditioning against advanced pancreatic cancer: a Japanese survey.采用低强度预处理的异基因造血干细胞移植治疗晚期胰腺癌：一项日本的调查。
Bone Marrow Transplant. 2008 Jul;42(2):99-103. doi: 10.1038/bmt.2008.94. Epub 2008 Apr 7.
7
Fludarabine-melphalan as a preparative regimen for reduced-intensity conditioning allogeneic stem cell transplantation in relapsed and refractory Hodgkin's lymphoma: the updated M.D. Anderson Cancer Center experience.氟达拉滨-美法仑作为复发难治性霍奇金淋巴瘤减低剂量预处理异基因干细胞移植的预处理方案：MD安德森癌症中心的最新经验
Haematologica. 2008 Feb;93(2):257-64. doi: 10.3324/haematol.11828. Epub 2008 Jan 26.
8
Questions about gemcitabine dose rate: answered or unanswered?关于吉西他滨剂量率的问题：已解答还是未解答？
J Clin Oncol. 2007 Dec 20;25(36):5691-4. doi: 10.1200/JCO.2007.13.6879.
9
Clinical evidence of a graft-versus-Hodgkin's-lymphoma effect after reduced-intensity allogeneic transplantation.减低强度异基因移植后移植物抗霍奇金淋巴瘤效应的临床证据
Lancet. 2005;365(9475):1934-41. doi: 10.1016/S0140-6736(05)66659-7.
10
Preclinical evaluation of gemcitabine combination regimens for application in acute myeloid leukemia.吉西他滨联合方案用于急性髓系白血病的临床前评估
Clin Cancer Res. 2005 Jun 1;11(11):4225-33. doi: 10.1158/1078-0432.CCR-04-2106.

Gemcitabine, fludarabine and melphalan as a reduced-intensity conditioning regimen for allogeneic stem cell transplant in relapsed and refractory Hodgkin lymphoma: preliminary results.

作者信息

Anderlini Paolo, Saliba Rima M, Ledesma Celina, Chancoco Christina, Alousi Amin M, Shpall Elizabeth J, Popat Uday R, Hosing Chitra M, Khouri Issa F, Nieto Yago, Ciurea Stefan, Younes Anas, Fanale Michelle A, Acholonu Sandra, Valverde Rosamar, Champlin Richard E

出版信息

Leuk Lymphoma. 2012 Mar;53(3):499-502. doi: 10.3109/10428194.2011.615427. Epub 2011 Oct 24.

DOI:10.3109/10428194.2011.615427
PMID:21859247
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4245073/
Abstract
摘要