Toydemir Toygar, Tekin Koray, Yerdel Mehmet Ali
General Surgery Department, Istanbul Surgery Hospital, Nisantasi-Istanbul, Turkey.
J Laparoendosc Adv Surg Tech A. 2011 Oct;21(8):669-76. doi: 10.1089/lap.2011.0038. Epub 2011 Aug 22.
This study was designed to analyze the outcomes of Nissen fundoplication (NF) versus Toupet fundoplication (TF) in patients undergoing laparoscopic antireflux surgery (LARS).
All perioperative data, operative/postoperative complications, and follow-up data were prospectively recorded. All patients were seen on the 2nd month postoperatively and by yearly intervals thereafter. All patients have at least 12-month follow-up. Using SPSS software, groups were compared by t-test and chi-square tests as appropriate.
One thousand consecutive patients underwent primary LARS from May 2004 to August 2009. Six hundred eighty-four patients had NF and 316 had TF fundoplication. The mean follow-up of the NF (51.26 months) group was slightly longer than the TF group (43.53 months) (P=.018). There was no mortality and conversion. Esophageal perforation, jejunal perforation, and pulmonary emboli were the sole three major complications in separate patients. Dysphagia occurred in 15.4% and 9.9% in NF and TF, respectively (P=.001). Corresponding numbers for bloating were 19.6% and 10.8% in NF and TF, respectively (P=.001). Seventeen patients underwent reinterventions such as dilatation and re-do surgery and all 17 were in the NF group (P<.05). All other minor complications were similar except hiccups, which were seen in 30 patients and all were in the NF group (P<.05). Recurrence of reflux was observed in 1.8% and 2.2% of the NF and TF, respectively (P=.620).
Both NF and TF are effective procedures in controlling the acid-reflux symptoms. The functional side effects appear more often in the NF group. These side effects can be minimized and reinterventions for severe/prolonged dysphagia can be avoided with TF.
本研究旨在分析接受腹腔镜抗反流手术(LARS)的患者中,nissen胃底折叠术(NF)与Toupet胃底折叠术(TF)的治疗效果。
前瞻性记录所有围手术期数据、手术/术后并发症及随访数据。所有患者在术后第2个月就诊,此后每年随访一次。所有患者至少随访12个月。使用SPSS软件,根据情况采用t检验和卡方检验对组间进行比较。
2004年5月至2009年8月,连续1000例患者接受了初次LARS。684例患者接受了NF,316例患者接受了TF胃底折叠术。NF组的平均随访时间(51.26个月)略长于TF组(43.53个月)(P = 0.018)。无死亡病例及中转开腹情况。食管穿孔、空肠穿孔和肺栓塞分别是3例不同患者的唯一严重并发症。NF组和TF组吞咽困难的发生率分别为15.4%和9.9%(P = 0.001)。腹胀的相应发生率在NF组和TF组分别为19.6%和10.8%(P = 0.001)。17例患者接受了诸如扩张和再次手术等再次干预,所有17例均在NF组(P < 0.05)。除呃逆外,所有其他轻微并发症相似,呃逆见于30例患者,均在NF组(P < 0.05)。NF组和TF组反流复发率分别为1.8%和2.2%(P = 0.620)。
NF和TF在控制胃酸反流症状方面均有效。NF组的功能性副作用更为常见。采用TF可将这些副作用降至最低,并避免对严重/持续性吞咽困难进行再次干预。