Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, LVR-Klinikum Düsseldorf, Bergische Landstrasse 2, D-40629 Düsseldorf, Germany.
Schizophr Bull. 2011 Sep;37 Suppl 2(Suppl 2):S5-12. doi: 10.1093/schbul/sbr078.
Integrative models of the etiopathogesnesis of psychotic disorders are needed since a wealth of information from such diverse fields as neurobiology, psychology, and the social sciences is currently changing the concepts of mental disorders. Several approaches to integrate these streams of information into coherent concepts of psychosis are feasible and will need to be assessed in future experimental studies. Common to these concepts are the notion of psychotic disorders as brain disorders and a polythetic approach in that it is increasingly realized that a multitude of interindividually partially different pathogenetic factors interact in individual persons in a complex fashion resulting in the clinical symptoms of psychosis.
需要精神障碍发病机制的综合模型，因为目前来自神经生物学、心理学和社会科学等不同领域的大量信息正在改变精神障碍的概念。有几种方法可以将这些信息流整合到连贯的精神病概念中，这些方法在未来的实验研究中需要进行评估。这些概念的共同点是将精神障碍视为大脑疾病，以及一种多元方法，即越来越多的人认识到，多种个体间部分不同的发病因素以复杂的方式相互作用，导致精神症状的出现。
