Adesanmi T A, Okafor H U, Okoro A B, Mafe A G
Emel Hospital Festac, Lagos, Nigeria.
Niger J Clin Pract. 2011 Apr-Jun;14(2):195-200. doi: 10.4103/1119-3077.84015.
This cross-sectional study was conducted to evaluate the diagnostic performance of a new rapid immunochromatographic test named "Paracheck pf" in the diagnosis of malaria in Nigerian children.
A total of 380 Nigerian children aged between 6 and 59 months who presented at the University of Nigeria Teaching Hospital (UNTH) Enugu with fever and no obvious focus of any other infection were consecutively recruited. Malaria parasitemia was determined using simple microscopy and "Paracheck pf".
"Paracheck pf" has the following diagnostic performance characteristics: Sensitivity of 82%, specificity of 91.5%, negative predictive value of 91.5%, positive predictive value of 82%, a strong positive correlation between parasite density and test sensitivity, and a detection limit of 397 parasites/μl.
The test is, therefore, recommended for the use in Nigerian children aged between 6 and 59 months in Enugu for the diagnosis of malaria, but negative results should be cautiously interpreted in infants because symptomatic malaria may occur in these children at parasite densities as low as 100/μl.
本横断面研究旨在评估一种名为“Paracheck pf”的新型快速免疫层析试验在尼日利亚儿童疟疾诊断中的诊断性能。
连续招募了380名年龄在6至59个月之间、因发热且无其他明显感染病灶而到尼日利亚大学教学医院（埃努古）就诊的尼日利亚儿童。使用简易显微镜和“Paracheck pf”检测疟原虫血症。
“Paracheck pf”具有以下诊断性能特征：灵敏度为82%，特异性为91.5%，阴性预测值为91.5%，阳性预测值为82%，寄生虫密度与检测灵敏度之间呈强正相关，检测限为397个寄生虫/微升。
因此，推荐该试验用于埃努古6至59个月的尼日利亚儿童疟疾诊断，但对于婴儿，阴性结果应谨慎解读，因为这些儿童在寄生虫密度低至100/微升时也可能出现有症状的疟疾。
