Department of Medicine, Faculty of Medicine, Kuwait University, and Department of Dermatology, Farwaniya Hospital, Farwaniya, Kuwait.
Indian J Dermatol Venereol Leprol. 2011 Sep-Oct;77(5):571-6. doi: 10.4103/0378-6323.84059.
There is scarce published data on late onset vitiligo. All the studies showing association of audiological abnormalities have been done on younger age group of patients.
To study the clinical characteristics of the patients with late onset vitiligo. Also, to investigate the audiological abnormalities seen in these patients and compare them with age and sex matched healthy volunteers.
One hundred and ninety-seven consecutive patients developing vitiligo after the age of 40 were studied. These patients were examined for the audiological abnormalities, and compared with those seen in age and sex matched healthy volunteers.
Vitiligo started between 40 and 50 years of age in 68.02% of our patients. Vitiligo vulgaris was the commonest clinical pattern, and most patients reported onset of their vitiligo on the upper extremities. Fifty four had diabetes mellitus, 19 patients had autoimmune thyroid diseases, and 32 showed hypoacusis on audiometric examination. Eighteen controls (age and sex matched healthy volunteers) also showed hypoacusis. The difference in frequency was not significant (22.37% vs 18%, χ2-test, P>0.05). The sensorineural type of audiologic impairment was more commonly seen both in patients as well as in controls.
Late onset vitiligo was not found to have statistically significant association with audiological abnormalities in this study.
关于发病较晚的白癜风，目前仅有少量相关数据。所有表明听力异常与白癜风相关的研究都集中在年龄较小的患者群体中。
研究发病较晚的白癜风患者的临床特征。同时，调查这些患者的听力异常情况，并与年龄和性别匹配的健康志愿者进行比较。
共研究了 197 名年龄在 40 岁以后发病的白癜风患者。对这些患者进行听力异常检查，并与年龄和性别匹配的健康志愿者进行比较。
我们的患者中，68.02%的患者在 40 到 50 岁之间发病。白癜风最常见的临床类型是寻常型，大多数患者报告其白癜风首先出现在上肢。54 名患者患有糖尿病，19 名患者患有自身免疫性甲状腺疾病，32 名患者在听力检查中出现听力下降。18 名对照（年龄和性别匹配的健康志愿者）也表现出听力下降。频率差异无统计学意义（22.37%比 18%，卡方检验，P>0.05）。在患者和对照组中，均更常出现感觉神经性听力损伤类型。
在本研究中，发病较晚的白癜风与听力异常之间没有统计学上的显著关联。
