Department of Dermatology, Skin Research Center, Shahid Beheshti Medical University, Shohada-e-Tajrish Hospital, Tehran, Iran.
Indian J Dermatol Venereol Leprol. 2011 Sep-Oct;77(5):587-90. doi: 10.4103/0378-6323.84064.
Langerhans cell histiocytosis (LCH) is a rare disease and generally affects children under 15 years of age. Adult onset form and cutaneous features at presentation are uncommon. There are some options for treatment of the skin lesions of LCH such as topical and intralesional corticosteroid, nitrogen mustard, etc., which are not completely curative. Herein, we report a case of perianal LCH in a 20-year-old man with one-year history of recalcitrant well-demarcated, erythematous, and ulcerated plaque surrounding the anal orifice, with pain and difficulty in defecation that was successfully treated with thalidomide.
朗格汉斯细胞组织细胞增生症（LCH）是一种罕见疾病，通常影响 15 岁以下的儿童。成人发病形式和初诊时的皮肤表现并不常见。LCH 的皮肤病变有一些治疗选择，如局部和皮损内皮质类固醇、氮芥等，但并非完全治愈。本文报告了一例 20 岁男性肛周 LCH，患者肛周有一年病史的顽固性边界清楚的红斑和溃疡性斑块，伴有肛门周围疼痛和排便困难，使用沙利度胺成功治疗。
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