Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
J Gynecol Oncol. 2011 Jun 30;22(2):83-8. doi: 10.3802/jgo.2011.22.2.83.
It is clear that uterine carcinosarcomas and uterine papillary serous carcinomas (UPSC) have an adverse impact on outcome, but whether carcinosarcomas are worse than UPSC is unclear. The purpose of this study is to compare the pathology, survival, and disease recurrence of patients with carcinosarcomas to patients with UPSC.
The medical records of patients diagnosed with carcinosarcomas and UPSC between 1996 and 2009 at Samsung Medical Center were retrospectively analyzed. Information from pathology reports, site of relapse, time to recurrence, and death was obtained. The survival analysis was performed using the Kaplan-Meier method.
Thirty seven patients with carcinosarcomas and 38 patients with UPSC were identified during the study period. There was no significant difference in clinical characteristics including age, body mass index, proportion with advanced stage disease, rate of optimal debulking, and adjuvant treatment used. In addition, the pathology showed no significant difference in tumor size, myometrial involvement, lymphovascular invasion, peritoneal cytology, cervical invasion, and lymph node involvement. Patients with carcinosarcomas had similar patterns of relapse as the patients with UPSC. There was no difference in the progression-free and overall survival between the carcinosarcomas and UPSC patients (p=0.804 and p=0.651, respectively).
Patients with carcinosarcomas had similar clinicopathological features compared to the patients with UPSC.
子宫癌肉瘤和子宫乳头状浆液性癌（UPSC）对预后有明显影响，但癌肉瘤是否比 UPSC 更差尚不清楚。本研究旨在比较癌肉瘤患者与 UPSC 患者的病理、生存和疾病复发情况。
回顾性分析了 1996 年至 2009 年在三星医疗中心诊断为癌肉瘤和 UPSC 的患者的病历。获取了病理报告、复发部位、复发时间和死亡信息。采用 Kaplan-Meier 法进行生存分析。
研究期间共发现 37 例癌肉瘤患者和 38 例 UPSC 患者。临床特征如年龄、体重指数、晚期疾病比例、最佳减瘤率和辅助治疗使用情况无显著差异。此外，肿瘤大小、肌层浸润、脉管侵犯、腹腔细胞学、宫颈侵犯和淋巴结侵犯等病理学表现无显著差异。癌肉瘤患者的复发模式与 UPSC 患者相似。癌肉瘤和 UPSC 患者的无进展生存期和总生存期无差异（p=0.804 和 p=0.651）。
与 UPSC 患者相比，癌肉瘤患者具有相似的临床病理特征。
