Division of Johnson & Johnson Consumer Companies, Scientific and Professional Affairs, Research and Development, Johnson & Johnson Consumer & Personal Healthcare Products Worldwide, Morris Plains, NJ, United States of America.
Braz Oral Res. 2011 Jul-Aug;25(4):338-44. doi: 10.1590/s1806-83242011000400010.
Two antimicrobial agents, a fixed combination of essential oils (EOs) and 0.07% cetylpyridinium chloride (CPC) are found in commercially available mouthrinses, Listerine® Antiseptic and Crest® Pro HealthTM, respectively. Both mouthrinses have been shown to control dental plaque and gingivitis in short and longer term studies. The aim of this study was to determine the comparative effectiveness of these two mouthrinses using a 2-week experimental gingivitis model. Qualified subjects were randomly assigned to one of three mouthrinse groups: a fixed combination of EOs, 0.07% CPC, or negative control (C) rinse. Following baseline clinical assessments and a dental prophylaxis, subjects began a two-week period in which they rinsed twice daily with their assigned rinse and abstained from any mechanical oral hygiene procedures or other oral care products. Subjects were reassessed at the end of the two-week period. One hundred and forty-seven subjects were randomized and 142 completed this study. After two weeks use, the EOs rinse was superior (p < 0.011) to the CPC rinse in inhibiting the development of gingivitis, plaque, and bleeding, with 9.4% and 6.6% reductions compared to CPC for gingivitis and plaque, respectively. Both rinses were superior to the negative control rinse (p < 0.001). This study demonstrates that the essential oil-containing mouthrinse has superior antiplaque/antigingivitis effectiveness compared to the 0.07% CPC-containing mouthrinse without mechanical oral hygiene influence.
两种抗菌剂，一种是植物精油（EOs）的固定组合，另一种是 0.07%西吡氯铵（CPC），存在于市售的漱口水中，分别是李施德林®抗菌漱口水和佳洁士®Pro-HealthTM。这两种漱口液都已被证明可以在短期和长期研究中控制牙菌斑和牙龈炎。本研究旨在使用为期两周的实验性牙龈炎模型来确定这两种漱口液的比较效果。合格的受试者被随机分配到三种漱口液组之一：植物精油的固定组合、0.07% CPC 或阴性对照（C）漱口液。在基线临床评估和牙齿洁治后，受试者开始为期两周的时间，每天用指定的漱口液漱口两次，并避免任何机械口腔卫生程序或其他口腔护理产品。在两周结束时对受试者进行重新评估。共有 147 名受试者被随机分组，其中 142 名完成了这项研究。经过两周的使用，EOs 漱口液在抑制牙龈炎、牙菌斑和出血的发展方面优于 CPC 漱口液（p<0.011），与 CPC 相比，牙龈炎和牙菌斑分别减少了 9.4%和 6.6%。两种漱口液均优于阴性对照组（p<0.001）。本研究表明，含植物精油的漱口液在抗菌斑/抗牙龈炎方面的效果优于含 0.07% CPC 的漱口液，且不受机械口腔卫生的影响。
