Wu Yong-Ming, Bai Lin, Zhang Zeng-Qiang, Zheng Jin-Long, Han Li-Xin, Shu Si-Yun
Department of Neurology of Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Sheng Li Xue Bao. 2011 Aug 25;63(4):319-24.
To investigate the neuronal mechanism of retrieval of long-term digital memory in healthy volunteers, functional magnetic resonance imaging (fMRI) technique was used in the study. Twenty-two right-handed volunteers were subjected to a long-term digital memory test with block-design. The memory task and control task were adopted in the experiment alternatively. The fMRI data were recorded by a Siemens 1.5T MR machine and analyzed by SPM99. The activated brain regions were shown in the Talairach coordinate. The results showed that the Brodmann's area (BA) 9 region in left middle frontal gyrus was the most activated cortex during the long-term digital memory task. The left medial frontal gyrus, left inferior frontal gyrus, right inferior frontal gyrus, cingulate gyrus, left inferior parietal lobule, left superior parietal lobule, right superior parietal lobule, right middle temporal gyrus, left lingual gyrus, left middle occipital gyrus, right middle brain, cerebellum and right caudate nucleus tail were also involved. The activation in cortices showed obvious left predominance. It is suggested that a series of brain regions with left predominance are involved in long-term digital memory. Left lateral frontal cortex would be the most important structure for information extraction, while the other cortices and their connections may be important for processing and long-term storage of digital information.
为研究健康志愿者长期数字记忆提取的神经机制，本研究采用功能磁共振成像（fMRI）技术。22名右利手志愿者接受了采用组块设计的长期数字记忆测试。实验中交替采用记忆任务和对照任务。fMRI数据由西门子1.5T磁共振机器记录，并采用SPM99进行分析。激活的脑区以Talairach坐标显示。结果表明，在长期数字记忆任务中，左侧额中回的布罗德曼区（BA）9区是激活最明显的皮层。左侧额内侧回、左侧额下回、右侧额下回、扣带回、左侧顶下小叶、左侧顶上小叶、右侧顶上小叶、右侧颞中回、左侧舌回、左侧枕中回、右侧脑中部、小脑和右侧尾状核尾部也参与其中。皮层激活表现出明显的左侧优势。提示一系列以左侧优势为主的脑区参与长期数字记忆。左侧额外侧皮层可能是信息提取的最重要结构，而其他皮层及其连接可能对数字信息的处理和长期存储很重要。
