基于低频振幅分数分析揭示的慢性吸烟者的自发脑活动：一项静息态功能磁共振成像研究
Spontaneous brain activity in chronic smokers revealed by fractional amplitude of low frequency fluctuation analysis: a resting state functional magnetic resonance imaging study.
作者信息
Chu Shuilian, Xiao Dan, Wang Shuangkun, Peng Peng, Xie Teng, He Yong, Wang Chen
机构信息
Beijing Chao Yang Hospital, Capital Medical University, Beijing 100020, China; World Health Organization Collaborating Centre for Tobacco and Health, Beijing Institute of Respiratory Medicine, Beijing 100020, China; Department of Respiratory Medicine, Capital Medical University, Beijing 100069, China.
Beijing Chao Yang Hospital, Capital Medical University, Beijing 100020, China; World Health Organization Collaborating Centre for Tobacco and Health, Beijing Institute of Respiratory Medicine, Beijing 100020, China; Department of Respiratory Medicine, Capital Medical University, Beijing 100069, China. Email:
出版信息
Chin Med J (Engl). 2014;127(8):1504-9.
BACKGROUND
Nicotine is primarily rsponsible for the highly addictive properties of cigarettes. Similar to other substances, nicotine dependence is related to many important brain regions, particular in mesolimbic reward circuit. This study was to further reveal the alteration of brain function activity during resting state in chronic smokers by fractional amplitude of low frequency fluctuation (fALFF) based on functional magnetic resonance imaging (fMRI), in order to provide the evidence of neurobiological mechanism of smoking.
METHODS
This case control study involved twenty healthy smokers and nineteen healthy nonsmokers recruited by advertisement. Sociodemographic, smoking related characteristics and fMRI images were collected and the data analyzed.
RESULTS
Compared with nonsmokers, smokers showed fALFF increased significantly in the left middle occipital gyrus, left limbic lobe and left cerebellum posterior lobe but decreases in the right middle frontal gyrus, right superior temporal gyrus, right extra nuclear, left postcentral gyrus and left cerebellum anterior lobe (cluster size >100 voxels). Compared with light smokers (pack years ≤ 20), heavy smokers (pack years >20) showed fALFF increased significantly in the right superior temporal gyrus, right precentral gyrus, and right occipital lobe/cuneus but decreased in the right/left limbic lobe/cingulate gyrus, right/left frontal lobe/sub gyral, right/left cerebellum posterior lobe (cluster size >50 voxels). Compared with nonsevere nicotine dependent smokers (Fagerstrőm test for nicotine dependence, score ≤ 6), severe nicotine dependent smokers (score >6) showed fALFF increased significantly in the right/left middle frontal gyrus, right superior frontal gyrus and left inferior parietal lobule but decreased in the left limbic lobe/cingulate gyrus (cluster size >25 voxels).
CONCLUSIONS
In smokers during rest, the activity of addiction related regions were increased and the activity of smoking feeling, memory, related regions were also changed. The resting state activity changes in many regions were associated with the cumulative amount of nicotine intake and the severity of nicotine dependence.
背景
尼古丁是香烟具有高度成瘾性的主要原因。与其他物质类似，尼古丁依赖与许多重要脑区有关，尤其是中脑边缘奖赏回路。本研究旨在基于功能磁共振成像（fMRI），通过低频振幅分数（fALFF）进一步揭示慢性吸烟者静息状态下脑功能活动的改变，以提供吸烟神经生物学机制的证据。
方法
本病例对照研究通过广告招募了20名健康吸烟者和19名健康非吸烟者。收集社会人口统计学、吸烟相关特征及fMRI图像并进行数据分析。
结果
与非吸烟者相比，吸烟者左侧枕中回、左侧边缘叶和左侧小脑后叶的fALFF显著增加，但右侧额中回、右侧颞上回、右侧核外、左侧中央后回和左侧小脑前叶的fALFF降低（簇大小>100体素）。与轻度吸烟者（吸烟包年数≤20）相比，重度吸烟者（吸烟包年数>20）右侧颞上回、右侧中央前回和右侧枕叶/楔叶的fALFF显著增加，但右侧/左侧边缘叶/扣带回、右侧/左侧额叶/脑回下、右侧/左侧小脑后叶的fALFF降低（簇大小>50体素）。与非重度尼古丁依赖吸烟者（尼古丁依赖的Fagerstrőm测试得分≤6）相比，重度尼古丁依赖吸烟者（得分>6）右侧/左侧额中回、右侧额上回和左侧顶下小叶的fALFF显著增加，但左侧边缘叶/扣带回的fALFF降低（簇大小>25体素）。
结论
吸烟者在静息状态下，成瘾相关脑区的活动增加，与吸烟感觉、记忆相关脑区的活动也发生了变化。许多脑区的静息状态活动变化与尼古丁摄入量的累积和尼古丁依赖的严重程度有关。
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