钯催化通过 C-H 键活化的恶唑 C4-烯烃化反应：官能化氨基醇和氨基酸衍生物的差异合成。

Pd-catalyzed C4-olefination of oxazoles via C-H bond activation: divergent synthesis of functionalized amino alcohol and amino acid derivatives.

机构信息

Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620, USA.

出版信息

Org Lett. 2011 Oct 7;13(19):5040-3. doi: 10.1021/ol201865h. Epub 2011 Aug 23.

DOI:10.1021/ol201865h

Abstract

A Pd-catalyzed C4-olefination of oxazoles via C-H bond activation under mild conditions was achieved. The reaction was shown to be general over a range of substrates. New protocols for the divergent transformation of these products to provide functionalized amino alcohol and amino acid derivatives have also been established.

摘要

钯催化的通过 C-H 键活化的恶唑 C4-烯烃化反应在温和条件下实现。该反应在一系列底物中表现出普遍适用性。还建立了这些产物的发散转化的新方案，以提供功能化的氨基醇和氨基酸衍生物。