Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001 Leuven, Belgium.
Organic Chemistry Department, Science Faculty, Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya street 6, RU-117198 Moscow, Russia.
Molecules. 2020 Oct 27;25(21):4970. doi: 10.3390/molecules25214970.
The transition metal-catalyzed C-H bond functionalization of azoles has emerged as one of the most important strategies to decorate these biologically important scaffolds. Despite significant progress in the C-H functionalization of various heteroarenes, the regioselective alkylation and alkenylation of azoles are still arduous transformations in many cases. This review covers recent advances in the direct C-H alkenylation, alkylation and alkynylation of azoles utilizing transition metal-catalysis. Moreover, the limitations of different strategies, chemoselectivity and regioselectivity issues will be discussed in this review.
过渡金属催化的唑类 C-H 键功能化已成为修饰这些具有生物重要性的支架的最重要策略之一。尽管在各种杂芳烃的 C-H 功能化方面取得了重大进展，但在许多情况下，唑类的区域选择性烷基化和烯基化仍然是艰巨的转化。本综述涵盖了利用过渡金属催化直接 C-H 烯基化、烷基化和炔基化唑类的最新进展。此外，本综述还将讨论不同策略的局限性、化学选择性和区域选择性问题。
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