人类免疫缺陷病毒1型gp160的羧基末端限制了其在转染细胞系中的蛋白水解加工和转运。
The carboxy terminus of human immunodeficiency virus type 1 gp160 limits its proteolytic processing and transport in transfected cell lines.
作者信息
Haffar O K, Nakamura G R, Berman P W
机构信息
Department of Developmental Biology, Genetech Inc., South San Francisco, California 94080.
出版信息
J Virol. 1990 Jun;64(6):3100-3. doi: 10.1128/JVI.64.6.3100-3103.1990.
Abstract
Mutagenesis of the transmembrane domain and cytoplasmic tail of human immunodeficiency virus type 1 envelope glycoprotein gp160 revealed that its intracellular transport and processing in transfected cell lines were modulated by a functional domain included in the carboxy-terminal sequence consisting of residues 751 to 856.
摘要
对人类免疫缺陷病毒1型包膜糖蛋白gp160跨膜结构域和胞质尾的诱变研究表明，其在转染细胞系中的细胞内运输和加工过程受到羧基末端序列（由751至856位残基组成）中一个功能结构域的调控。
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