弗林蛋白酶对人类免疫缺陷病毒糖蛋白的合理及不合理切割
Legitimate and illegitimate cleavage of human immunodeficiency virus glycoproteins by furin.
作者信息
Morikawa Y, Barsov E, Jones I
机构信息
NERC Institute of Virology, Oxford, United Kingdom.
出版信息
J Virol. 1993 Jun;67(6):3601-4. doi: 10.1128/JVI.67.6.3601-3604.1993.
Abstract
Coexpression of human immunodeficiency virus type 1 glycoproteins with the subtilisin-like protease furin leads to processing of gp160 and gp140, a truncated form of gp160, to gp120. In addition, we show that gp120 itself is further cleaved by furin at sites near the primary cleavage site and within the V3 loop.
摘要
人类免疫缺陷病毒1型糖蛋白与枯草杆菌蛋白酶样蛋白酶弗林蛋白酶的共表达导致gp160和gp140（gp160的一种截短形式）加工成gp120。此外，我们还表明，gp120自身在靠近主要切割位点和V3环内的位点被弗林蛋白酶进一步切割。
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