Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Br J Nutr. 2011 Nov;106(9):1291-6. doi: 10.1017/S000711451100287X. Epub 2011 Aug 24.
Health claims for probiotics are evaluated by the Panel on Dietetic Products, Nutrition and Allergies of the European Food Safety Authority. Despite a substantial amount of basic and clinical research on the beneficial effects of probiotics, all of the evaluated claim applications thus far have received a negative opinion. With the restrictions on the use of clinical endpoints, validated biomarkers for gut health and immune health in relation to reduction in disease risk are needed. Clear-cut criteria for design as well as evaluation of future studies are needed. An open dialogue between basic and clinical scientists, regulatory authorities, food and nutrition industry, and consumers could bridge the gap between science and marketing of probiotics.
益生菌的健康声称由欧洲食品安全局的饮食产品、营养和过敏小组进行评估。尽管有大量关于益生菌有益效果的基础和临床研究，但迄今为止，所有评估的声称申请都得到了否定意见。由于对临床终点的使用限制，需要与疾病风险降低相关的肠道健康和免疫健康的验证生物标志物。需要明确的设计和未来研究评估标准。基础和临床科学家、监管机构、食品和营养行业以及消费者之间的公开对话可以弥合益生菌科学和营销之间的差距。
