Kleinschmidt S, Peters M, Wohlsein P
Department of Pathology, University of Veterinary Medicine, Bünteweg 17, D-30559 Hannover, Germany.
J Comp Pathol. 2012 Feb-Apr;146(2-3):283-7. doi: 10.1016/j.jcpa.2011.07.001. Epub 2011 Aug 20.
This report describes a central nervous system (CNS) neuroblastoma in a wild deer (Capreolus capreolus) of approximate age 10 years. The doe was found in a barn with a fractured right forelimb and was shot. The animal was submitted for post-mortem examination in order to exclude rabies. The tumour was located in the midline of the mesencephalon with replacement of thalamus and parts of the hypothalamus and infiltration into the adjacent neuroparenchyma and the right lateral and third ventricles. Microscopically, the neoplastic cells were arranged in sheets and nests forming Homer-Wright- and pseudorosettes. Immunohistochemically, the tumour cells expressed neuron-specific enolase, synaptophysin, doublecortin and neurofilament. This is the first report of an infiltrative CNS neuroblastoma in a wild deer.
本报告描述了一只年龄约10岁的野生狍（Capreolus capreolus）的中枢神经系统（CNS）神经母细胞瘤。这只母狍在一个谷仓中被发现，右前肢骨折，随后被射杀。该动物被送去进行尸检以排除狂犬病。肿瘤位于中脑中线，取代了丘脑和部分下丘脑，并浸润到相邻的神经实质以及右侧侧脑室和第三脑室。显微镜下，肿瘤细胞呈片状和巢状排列，形成霍纳-赖特（Homer-Wright）假菊形团。免疫组织化学检查显示，肿瘤细胞表达神经元特异性烯醇化酶、突触素、双皮质素和神经丝。这是野生狍中浸润性中枢神经系统神经母细胞瘤的首例报告。
