Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Res Vet Sci. 2012 Aug;93(1):168-71. doi: 10.1016/j.rvsc.2011.07.014. Epub 2011 Aug 20.
γδ T cells represent an unconventional subset of T lymphocytes that are abundant in epithelial tissues and serve as an early immune defense against microbes. We have, for the first time, identified γδ T cells in steady-state thoracic duct lymph (TDL) from rats. The lymph contains γδ T cells expressing CD8 but not CD4, CD25, MHC-II or CD103. The percentage of TDL γδ T cells in rats does not change when the mesenteric lymph nodes (MLN) are surgically removed. Our data suggest that a proportion of γδ T cells migrate from the intestine into rat TDL, under steady-state conditions.
γδ T 细胞是 T 淋巴细胞的一个非常规亚群，在表皮组织中丰富存在，是抵御微生物的早期免疫防御细胞。我们首次在稳定状态下大鼠胸导管淋巴（TDL）中鉴定出 γδ T 细胞。该淋巴液中表达 CD8 但不表达 CD4、CD25、MHC-II 或 CD103 的 γδ T 细胞。当肠系膜淋巴结（MLN）被手术切除时，大鼠 TDL 中的 γδ T 细胞百分比没有变化。我们的数据表明，在稳定状态下，一部分 γδ T 细胞从肠道迁移到大鼠 TDL 中。
