Laboratory for Biology of Reproduction, Institute INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.
Placenta. 2011 Nov;32(11):909-11. doi: 10.1016/j.placenta.2011.07.087. Epub 2011 Sep 8.
Galectins (gals) as multifunctional animal lectins are of great potential significance for establishment and function of the placenta, due to their capacity to modulate cellular functions including proliferation, adhesion, and invasion. Human trophoblast is known to express gal-1, gal-3 and gal-13 proteins, as well as mRNAs for gal-14, -16 and -17. This study was undertaken to establish cellular distribution of gal-8, not previously associated with trophoblast, since we have recently detected gal-8 RNA and protein in cytotrophoblast cell material. Results of immunolocalization showed that gal-8 was expressed by villous and extravillous cytotrophoblast.
半乳糖凝集素（galectins，gals）作为多功能动物凝集素，对于胎盘的建立和功能具有重要意义，因为它们能够调节细胞功能，包括增殖、黏附和侵袭。已知人类滋养层表达 gal-1、gal-3 和 gal-13 蛋白，以及 gal-14、-16 和 -17 的 mRNA。本研究旨在建立以前与滋养层无关的 gal-8 的细胞分布，因为我们最近在细胞滋养细胞物质中检测到 gal-8 RNA 和蛋白质。免疫定位结果表明，gal-8 由绒毛和绒毛外细胞滋养层表达。
