Jinnouchi Osamu, Kuwahara Tomomi, Ishida Shiro, Okano Yoshiro, Kasei Yasuko, Kunitomo Kazufumi, Takeda Noriaki
Department of Otolaryngology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
Auris Nasus Larynx. 2012 Aug;39(4):374-7. doi: 10.1016/j.anl.2011.07.007. Epub 2011 Aug 20.
Burow's solution, which contains 13% aluminum acetate, has been shown to be effective against chronic otitis media. Since the preparation of Burow's solution is time-consuming, its rapid preparation method has been recently developed. In this study, we evaluated the therapeutic effects of the modified Burow's solution on refractory otorrhea in patients with chronic suppurative otitis and its anti-microbial activity in vitro.
Fourteen ears of 12 patients with chronic otitis media, granular myringitis, otitis externa and postoperative mastoid cavity problems were treated topically with cotton swab/ball soaked with modified Burow's solution or its four-fold diluted ear drops once a week. We then examined the antimicrobial spectrum of modified Burow's solution against clinical bacterial isolates from otorrhea and laboratory bacterial strains in vitro.
In all ears, refractory otorrhea disappeared after 1-17 weeks treatment of modified Burow's solution with a mean of 5.4 weeks without apparent side-effects such as ototoxicity. Modified Burow's solution inactivated all Gram positive bacteria within 5min except Enterococcus species, all Gram negative bacteria including Pseudomonas aeruginosa within 30s and Candida albicans within 2min. In addition, modified Burow's solution inactivated MRSA completely within 5min, while 80.6% of MRSA survived even a 20-min contact with 0.3% ofloxacin.
These findings indicate that modified Burow's solution, in addition to bearing a broad antimicrobial activity, is as effective as the original Burow's solution in the treatment of chronic suppurative otitis.
含13%醋酸铝的布罗溶液已被证明对慢性中耳炎有效。由于布罗溶液的制备耗时，其快速制备方法最近已被开发出来。在本研究中，我们评估了改良布罗溶液对慢性化脓性中耳炎患者难治性耳漏的治疗效果及其体外抗菌活性。
对12例患有慢性中耳炎、颗粒性鼓膜炎、外耳道炎和术后乳突腔问题的患者的14只耳朵，每周一次用浸有改良布罗溶液或其四倍稀释耳液的棉签/棉球进行局部治疗。然后我们在体外检测了改良布罗溶液对耳漏临床分离菌株和实验室菌株的抗菌谱。
在所有耳朵中，用改良布罗溶液治疗1至17周后，难治性耳漏消失，平均为5.4周，且无明显副作用，如耳毒性。改良布罗溶液在5分钟内使所有革兰氏阳性菌（除肠球菌属外）失活，在30秒内使所有革兰氏阴性菌（包括铜绿假单胞菌）失活，在2分钟内使白色念珠菌失活。此外，改良布罗溶液在5分钟内完全使耐甲氧西林金黄色葡萄球菌（MRSA）失活，而80.6%的MRSA即使与0.3%氧氟沙星接触20分钟仍存活。
这些结果表明，改良布罗溶液除具有广泛的抗菌活性外，在治疗慢性化脓性中耳炎方面与原布罗溶液一样有效。
