Kashiwamura Masaaki, Chida Eiji, Matsumura Michiya, Nakamaru Yuuji, Suda Noriyuki, Terayama Yoshihiko, Fukuda Satoshi
Department of Otolaryngology, Medical School of Hokkaido University, Sapporo, Japan.
Otol Neurotol. 2004 Jan;25(1):9-13. doi: 10.1097/00129492-200401000-00002.
To determine the efficacy of Burow's solution as an otologic preparation for the treatment of chronic ear infection.
Two studies were included: 1) a prospective clinical study and 2) a laboratory study on antibacterial and antifungal effects.
A private otology practice and a laboratory study.
Fifty-eight patients with refractory otorrhea.
Diagnosis by otoscopy, audiometry, and bacteriology.
Burow's solution was mixed in solutions with four organisms: methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, Candida albicans, and Aspergillus. Soon after Burow's solution was mixed in the solutions with organisms, and 5, 10, and 20 minutes thereafter, the mixtures were cultured on agars. The numbers of the bacterial or fungal colonies were counted to evaluate the effect of Burow's solution.
Changes in the clinical findings of the ears, the symptom of otorrhea, and side effects were assessed.
Thirty-five (70%) of the 50 ears assessed were "cured" and 10 (20%) ears assessed were "improved." No significant side effect was observed. Regarding the laboratory study, the four organisms disappeared within 20 minutes after Burow's solution was mixed.
Burow's solution was considered to be an effective otologic preparation.
确定布罗溶液作为一种耳科制剂治疗慢性耳部感染的疗效。
包括两项研究：1）一项前瞻性临床研究和2）一项关于抗菌和抗真菌作用的实验室研究。
一家私人耳科诊所和一项实验室研究。
58例难治性耳漏患者。
通过耳镜检查、听力测定和细菌学进行诊断。
将布罗溶液与四种微生物混合于溶液中：耐甲氧西林金黄色葡萄球菌、耐青霉素肺炎链球菌、白色念珠菌和曲霉菌。在布罗溶液与含微生物的溶液混合后不久，以及此后5分钟、10分钟和20分钟，将混合物接种在琼脂上培养。计算细菌或真菌菌落数，以评估布罗溶液的效果。
评估耳部临床检查结果、耳漏症状和副作用的变化。
评估的50只耳朵中有35只（70%）“治愈”，10只（20%）耳朵“改善”。未观察到明显副作用。关于实验室研究，在布罗溶液混合后20分钟内，四种微生物均消失。
布罗溶液被认为是一种有效的耳科制剂。
