Department of Molecular, Cellular and Developmental Biology, Yale University, Howard Hughes Medical Institute, New Haven, CT 0652, USA.
Curr Opin Chem Biol. 2011 Oct;15(5):636-42. doi: 10.1016/j.cbpa.2011.07.019. Epub 2011 Aug 20.
It is becoming increasingly clear that RNA molecules play a major role in all aspects of metabolism. The conformational state and stability of RNA are controlled by RNA remodeling proteins, which are ubiquitous motor proteins in the cell. Here, we review advances in our understanding of the structure and function of three major structural families of RNA remodeling proteins, the hexameric ring proteins, the processive monomeric RNA translocase/helicases, and the functionally diverse DEAD-box remodeling proteins. New studies have revealed molecular mechanisms for coupling between ATP hydrolysis and unwinding, the physical basis for regulatory control by cofactors, and novel functions for RNA remodeling proteins.
越来越明显的是，RNA 分子在新陈代谢的各个方面都起着重要作用。RNA 构象状态和稳定性受 RNA 重塑蛋白控制，这些蛋白是细胞中普遍存在的马达蛋白。在这里，我们综述了对三种主要结构家族的 RNA 重塑蛋白（六聚体环蛋白、连续单体 RNA 转位酶/解旋酶和功能多样的 DEAD 盒重塑蛋白）的结构和功能的理解的进展。新的研究揭示了 ATP 水解和解旋之间的偶联的分子机制、辅因子调控的物理基础以及 RNA 重塑蛋白的新功能。
