英国新生儿病房中庆大霉素和万古霉素剂量及监测的变化。
Variation in gentamicin and vancomycin dosage and monitoring in UK neonatal units.
机构信息
Paediatric Infectious Disease Unit, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.
出版信息
J Antimicrob Chemother. 2011 Nov;66(11):2647-50. doi: 10.1093/jac/dkr351. Epub 2011 Aug 22.
BACKGROUND
Gentamicin and vancomycin are commonly used in neonatal units for the treatment of life-threatening infections. This study aimed to describe the dosage regimen and the approach to therapeutic drug monitoring (TDM) for both antibiotics in units that participate in a UK neonatal network.
METHODS
Questionnaires were sent to all units across the Extended Neonatal Network, requesting details of each unit's dosing regimen and TDM practice.
RESULTS
A total of 43 (of 114) units replied to the gentamicin questionnaire and 29 to the vancomycin questionnaire. Ten different gentamicin dosing regimens were used, depending on gestational age and weight. Most units (79%) followed British National Formulary for Children dosing guidance regarding vancomycin, but there were nine variations in TDM practice.
CONCLUSIONS
There is significant variation in gentamicin and vancomycin dosing regimens and TDM guidance across a UK network of neonatal units. The development of standardized, evidence-based protocols should be prioritized.
背景
庆大霉素和万古霉素常用于新生儿病房治疗危及生命的感染。本研究旨在描述参加英国新生儿网络的单位中这两种抗生素的剂量方案和治疗药物监测（TDM）方法。
方法
向扩展新生儿网络中的所有单位发送了问卷，要求提供每个单位的剂量方案和 TDM 实践的详细信息。
结果
共有 43 个（114 个中的）单位回复了庆大霉素问卷，29 个单位回复了万古霉素问卷。有 10 种不同的庆大霉素剂量方案，取决于胎龄和体重。大多数单位（79%）遵循英国儿童国家处方集关于万古霉素的剂量指南，但 TDM 实践存在 9 种变化。
结论
在英国新生儿病房网络中，庆大霉素和万古霉素的剂量方案和 TDM 指南存在显著差异。应优先制定标准化、基于证据的方案。
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