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In search of housekeeping pathways that regulate longevity.

作者信息

Beach Adam, Titorenko Vladimir I

出版信息

Cell Cycle. 2011 Sep 15;10(18):3042-4. doi: 10.4161/cc.10.18.16947.

DOI:10.4161/cc.10.18.16947
PMID:21862878
Abstract
摘要

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In search of housekeeping pathways that regulate longevity.寻找调节寿命的管家途径。
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How are peroxisomes formed? The role of the endoplasmic reticulum and peroxins.过氧化物酶体是如何形成的?内质网和过氧化物酶体蛋白的作用。
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Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.积聚在酵母线粒体中的石胆酸通过引起细胞蛋白质组的年龄相关变化,精心编排了一种抗衰老细胞模式的发展。
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Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions.石胆酸在热量限制条件下延缓酵母时序性衰老的机制。
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Some Metabolites Act as Second Messengers in Yeast Chronological Aging.
一些代谢物在酵母时序老化中充当第二信使。
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Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state.热量限制通过一种将细胞衰老与细胞周期调控、静止状态的维持、进入非静止状态以及在非静止状态下的存活相联系的机制,延长酵母的时序寿命。
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Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging.线粒体膜脂在酵母时序性衰老中发挥关键作用的潜在机制
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Cell-autonomous mechanisms of chronological aging in the yeast .酵母中时序衰老的细胞自主机制
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Empirical verification of evolutionary theories of aging.衰老进化理论的实证验证。
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Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes.发现能显著延缓酵母时序性衰老且对定义寿命的细胞过程有不同影响的植物提取物。
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