钯催化的 2-甲氧基亚氨基-2-芳基乙酸酯和乙酰胺的 C-H 乙酰化反应。
Palladium-catalyzed C-H acetoxylation of 2-methoxyimino-2-aryl-acetates and acetamides.
机构信息
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China.
出版信息
Org Biomol Chem. 2011 Oct 21;9(20):6895-8. doi: 10.1039/c1ob05887h. Epub 2011 Aug 23.
PMID:21863152
Abstract
Palladium-catalyzed C-H acetoxylation reactions of 2-methoxyimino-2-aryl-acetates and acetamides have been developed. These transformations feature excellent regioselectivity, wide substrate scope, and moderate to good yields. The product can be easily converted into naturally unprecedented α-amino acids in excellent yields.
摘要
钯催化的 2-甲氧基亚氨基-2-芳基乙酸酯和乙酰胺的 C-H 乙酰化反应已经被开发出来。这些转化具有优异的区域选择性、广泛的底物范围和中等至良好的产率。产物可以很容易地转化为具有优异产率的天然前所未有的α-氨基酸。
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