Islam Sameer, Cevik Cihan, Islam Ebtesam, Attaya Hosam, Nugent Kenneth
Department of Internal Medicine, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA.
J Heart Valve Dis. 2011 Jul;20(4):366-75.
Heyde's syndrome is an uncommon association between aortic stenosis and gastrointestinal bleeding. Although initially described during the late 1950s, with subsequent reports of a possible link between these disorders, controversy persists regarding the incidence, pathogenesis, and treatment of this syndrome. The main disagreements center on the actual association of aortic stenosis and angiodysplasia, though other controversies include the pathogenesis of Heyde's syndrome, ranging from von Willebrand factor deficiency and age-related degeneration to mucosal ischemia and cholesterol embolization. A variety of treatment modalities of the syndrome has been applied, including medical management, endoscopic therapy, embolization, and aortic valve replacement. Here, the controversies surrounding Heyde's syndrome, which focus on pathogenesis and treatment, are reviewed with the aim of providing a clearer understanding of the syndrome and the implications for patient care.
海德综合征是主动脉瓣狭窄与胃肠道出血之间的一种罕见关联。尽管最初在20世纪50年代末被描述，随后也有关于这些疾病之间可能联系的报道，但关于该综合征的发病率、发病机制和治疗仍存在争议。主要的分歧集中在主动脉瓣狭窄与血管发育异常的实际关联上，不过其他争议还包括海德综合征的发病机制，范围从血管性血友病因子缺乏和年龄相关退变到黏膜缺血和胆固醇栓塞。该综合征已应用了多种治疗方式，包括药物治疗、内镜治疗、栓塞和主动脉瓣置换。在此，围绕海德综合征的争议，主要集中在发病机制和治疗方面，进行了综述，目的是更清楚地了解该综合征及其对患者护理的影响。
