Buneeva O A, Medvedev A E
Biomed Khim. 2011 May-Jun;57(3):246-81. doi: 10.18097/pbmc20115703246.
Mitochondrial structural and functional abnormalities in Parkinson's disease and experimental animal models of this pathology are described. Special attention is paid to the inactivation of mitochondrial enzymes, mutations in mitochondrial and nuclear DNA, and genomic and proteomic research of mitochondrial proteins in Parkinson's disease and experimental parkinsonism of animals.
本文描述了帕金森病及其实验动物模型中线粒体的结构和功能异常。特别关注了线粒体酶的失活、线粒体和核DNA的突变,以及帕金森病和动物实验性帕金森病中线粒体蛋白质的基因组和蛋白质组研究。