Aristotle University, Thessalonifei, Greece.
Diabetes Res Clin Pract. 2011 Aug;93 Suppl 1:S105-8. doi: 10.1016/S0168-8227(11)70024-9.
Despite numerous publications according to which insulin promotes atherosclerosis, there are many observations in the last fifteen years suggesting that insulin has antiatherogenic properties. Insulin has vasodilatory, antithrombotic and anti-inflammatory effects. A good glycemic control contributes to the maximum efficiency of antiatherogenic action of insulin. Insulin resistance promotes the atherosclerotic process because of diminished insulin action and not because of hyperinsulinemia, since insulin secretion is getting lower during the years in type 2 diabetes.
尽管有大量文献表明胰岛素会促进动脉粥样硬化，但在过去的十五年中，有许多观察结果表明胰岛素具有抗动脉粥样硬化作用。胰岛素具有血管舒张、抗血栓和抗炎作用。良好的血糖控制有助于最大限度地发挥胰岛素的抗动脉粥样硬化作用。胰岛素抵抗会促进动脉粥样硬化进程，这是由于胰岛素作用减弱，而不是由于高胰岛素血症，因为在 2 型糖尿病中，胰岛素分泌会随着时间的推移而降低。
