Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany.
J Nutr Biochem. 2012 Aug;23(8):875-84. doi: 10.1016/j.jnutbio.2011.04.012. Epub 2011 Aug 23.
Curcuma longa L. has long been used as a medicinal plant in traditional Chinese medicine against abdominal disorders. Its active constituent curcumin has anti-inflammatory, chemopreventive and cytotoxic properties. In the present investigation, we have analyzed the cytotoxic activity of curcumin and four derivatives. Among these compounds, ethoxycurcumintrithiadiazolaminomethylcarbonate was the most cytotoxic one. The curcumin-type compounds were not cross-resistant to standard anticancer drugs and were not involved in ATP-binding cassette transporter-mediated multidrug resistance. A combined approach of messenger RNA-based microarray profiling, COMPARE analyses and signaling pathway analyses identified genes as determinants of sensitivity and resistance to curcumin and specific signaling routes involved in cellular response to curcumin. These genes may be useful as biomarkers to develop individualized treatment options in the future. From a nutritional point of view, it is a thriving perspective to further investigate whether C. longa may be used as a spice to improve cancer therapy.
姜黄在传统中药中被长期用作治疗腹部疾病的药用植物。其活性成分姜黄素具有抗炎、化学预防和细胞毒性作用。在本研究中，我们分析了姜黄素和四种衍生物的细胞毒性活性。在这些化合物中，乙氧基姜黄素三噻二唑氨甲酸盐的细胞毒性最强。姜黄素类化合物对标准抗癌药物没有交叉耐药性，也不参与三磷酸腺苷结合盒转运蛋白介导的多药耐药性。基于信使 RNA 的微阵列分析、比较分析和信号通路分析的综合方法确定了决定姜黄素敏感性和耐药性的基因，以及涉及细胞对姜黄素反应的特定信号通路。这些基因将来可能作为生物标志物用于开发个体化治疗方案。从营养的角度来看，进一步研究姜黄是否可以用作香料来改善癌症治疗是一个很有前途的方向。
