Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA.
Molecules. 2022 Dec 14;27(24):8891. doi: 10.3390/molecules27248891.
Breast cancer (BC), the most common malignancy in women, results from significant alterations in genetic and epigenetic mechanisms that alter multiple signaling pathways in growth and malignant progression, leading to limited long-term survival. Current studies with numerous drug therapies have shown that BC is a complex disease with tumor heterogeneity, rapidity, and dynamics of the tumor microenvironment that result in resistance to existing therapy. Targeting a single cell-signaling pathway is unlikely to treat or prevent BC. Curcumin (a natural yellow pigment), the principal ingredient in the spice turmeric, is well-documented for its diverse pharmacological properties including anti-cancer activity. However, its clinical application has been limited because of its low solubility, stability, and bioavailability. To overcome the limitation of curcumin, several modified curcumin conjugates and curcumin mimics were developed and studied for their anti-cancer properties. In this review, we have focused on the application of curcumin mimics and their conjugates for breast cancer.
乳腺癌（BC）是女性最常见的恶性肿瘤，源于遗传和表观遗传机制的重大改变，这些改变会改变生长和恶性进展中的多个信号通路，导致长期生存有限。目前，许多药物治疗的研究表明，BC 是一种具有肿瘤异质性、快速性和肿瘤微环境动力学的复杂疾病，导致对现有治疗的耐药性。靶向单一细胞信号通路不太可能治疗或预防 BC。姜黄素（一种天然黄色色素）是香料姜黄的主要成分，其具有多种药理学特性，包括抗癌活性，这已得到充分证明。然而，由于其低溶解度、稳定性和生物利用度，其临床应用受到限制。为了克服姜黄素的局限性，已经开发并研究了几种改性姜黄素缀合物和姜黄素类似物，以研究它们的抗癌特性。在这篇综述中，我们重点介绍了姜黄素类似物及其缀合物在乳腺癌中的应用。
