Diabetes and Nutritional Sciences Division, School of Medicine, King's College London, London, United Kingdom.
Am J Clin Nutr. 2011 Oct;94(4):973-80. doi: 10.3945/ajcn.111.018036. Epub 2011 Aug 24.
The dietary intake of n-3 (omega-3) long-chain PUFAs (LC-PUFAs) from fish may improve endothelial function and arterial stiffness.
The objective was to test the hypothesis that increasing intakes of n-3 LC-PUFAs-equivalent to the consumption of 1, 2, or 4 portions of oily fish per week-favorably affects endothelial function and arterial stiffness.
A parallel-design, randomized, double-blind study compared daily doses of 0.45, 0.9, and 1.8 g n-3 LC-PUFAs (EPA:DHA ratio of 1.51:1) with placebo (refined olive oil). The primary and secondary outcomes were changes in flow-mediated dilatation (FMD) of the brachial artery, arterial stiffness, and blood pressure. Nonsmoking men (n = 142) and women (n = 225) aged 45-70 y were randomly assigned to treatment for 12 mo; 312 subjects completed the intervention.
Compliance with the intervention was corroborated by significant dose-dependent increases in the proportions of EPA and DHA in erythrocyte lipids and a 16.5% reduction in serum triacylglycerol concentrations with 1.8 g n-3 LC-PUFAs/d. FMD was lower in men than in women (P < 0.0001) and decreased with age (ρ = 0.270, P < 0.001) but was not significantly (P = 0.781) related to n-3 LC-PUFA intake. The mean changes in FMD (95% CIs) compared with placebo were 0.1% (-0.9%, 1.1%), -0.3% (-1.3%, 0.6%), and -0.3% (-1.3%, 0.7%) with daily intakes of 0.45, 0.9, and 1.8 g n-3 LC-PUFAs, respectively. No significant treatment effects were noted for arterial stiffness and central mean or 24-h ambulatory blood pressure.
Intakes of n-3 LC-PUFAs ≤1.8 g/d do not improve endothelial function in healthy adults. The trial is registered at controlled-trials.com as ISRCTN66664610.
从鱼类中摄入 n-3（ω-3）长链多不饱和脂肪酸（LC-PUFA）可能改善内皮功能和动脉僵硬。
本研究旨在验证这样一个假设，即增加 n-3 LC-PUFA 的摄入量（相当于每周食用 1、2 或 4 份油性鱼）有利于改善内皮功能和动脉僵硬。
一项平行设计、随机、双盲研究比较了 0.45、0.9 和 1.8 g n-3 LC-PUFA（EPA:DHA 比值为 1.51:1）与安慰剂（精制橄榄油）的每日剂量。主要和次要结局是肱动脉血流介导的扩张（FMD）、动脉僵硬和血压的变化。不吸烟的男性（n=142）和女性（n=225）年龄 45-70 岁，随机分为治疗组，干预时间为 12 个月；312 名受试者完成了干预。
红细胞脂质中 EPA 和 DHA 的比例以及血清三酰甘油浓度降低 16.5%（1.8 g n-3 LC-PUFA/d）证实了干预的依从性。与女性相比，男性的 FMD 较低（P<0.0001），且随年龄增长而降低（ρ=0.270，P<0.001），但与 n-3 LC-PUFA 摄入量无显著相关性（P=0.781）。与安慰剂相比，FMD 的平均变化（95%CI）分别为 0.1%（-0.9%，1.1%）、-0.3%（-1.3%，0.6%）和-0.3%（-1.3%，0.7%），每日摄入 0.45、0.9 和 1.8 g n-3 LC-PUFA。动脉僵硬和中心平均或 24 小时动态血压无显著治疗作用。
健康成年人每日摄入 n-3 LC-PUFA≤1.8 g 不会改善内皮功能。该试验在 controlled-trials.com 上注册为 ISRCTN66664610。
