Jovanovic M, Soldatovic I, Janjic A, Vuksanovic A, Dzamic Z, Acimovic M, Hadzi-Djokic J
Urology Clinic, Clinical Center of Serbia, Belgrade, Serbia.
Urol Int. 2011;87(2):134-7. doi: 10.1159/000330246. Epub 2011 Aug 24.
To investigate the diagnostic value of the nuclear matrix protein 22 (NMP22) test in comparison to urine cytology for the detection of upper tract urothelial carcinoma.
Patients with transitional cell carcinoma of the upper urinary tract (n = 34) and patients with renal calculosis (n = 25) were included in this study. Voided urine samples and separated catheter urine specimens were assayed for NMP22 and cytological examination.
The sensitivity of the NMP22 test in separated and voided urine was 73.2 and 70.5%, respectively, compared to 64.7 and 58.8% of urine cytology. The specificity of the NMP22 test in separated and voided urine was 88 and 92%, respectively, compared to 96 and 96% of urine cytology. The combination of separated and voided urine is the best method because the sensitivity is 79.41% and specificity 88%. There is a high agreement of the NMP22 test in voided and separated urine (kappa = 0.795, p < 0.01), indicating that the voided urine is adequate for diagnosis.
The NMP22 test has higher sensitivity but lower specificity than cytology. The combination of these two tests could be a very useful diagnostic method for detection of upper urothelial tumors.
比较核基质蛋白22（NMP22）检测与尿细胞学检查对上尿路尿路上皮癌的诊断价值。
本研究纳入了34例上尿路移行细胞癌患者和25例肾石病患者。对晨尿样本和导尿分离样本进行NMP22检测及细胞学检查。
NMP22检测对导尿分离样本和晨尿样本的敏感性分别为73.2%和70.5%，而尿细胞学检查的敏感性分别为64.7%和58.8%。NMP22检测对导尿分离样本和晨尿样本的特异性分别为88%和92%，而尿细胞学检查的特异性分别为96%和96%。导尿分离样本和晨尿样本联合检测是最佳方法，其敏感性为79.41%，特异性为88%。NMP22检测在晨尿样本和导尿分离样本中的一致性较高（kappa = 0.795，p < 0.01），表明晨尿样本足以用于诊断。
NMP22检测的敏感性高于细胞学检查，但特异性较低。这两种检测方法联合应用可能是检测上尿路尿路上皮肿瘤非常有用的诊断方法。
