Kyd Jennelle, Krishnamurthy Ajay, McGrath John, Browne Jessica, Vahedi Fatemah
Institute for Health and Social Science Research, School of Medical and Applied Science, CQ University Australia, Rockhampton, Qld., Australia.
Adv Otorhinolaryngol. 2011;72:116-20. doi: 10.1159/000324654. Epub 2011 Aug 18.
The dynamic interactions of the major respiratory microbial pathogens are complex. An understanding of the impact on naturally acquired immune responses to respiratory polymicrobial commensal bacteria is slowly evolving. Maintaining a micro-floral balance and the host's ability to respond to imbalances associated with disease is critical. Studies of acquired immune responses have found that both antibody and cellular immune responses are suppressed by the presence of multiple bacteria when compared with colonization by the single microbe. Microbes interact with the mucosal epithelium through a range of receptor-ligand interactions, including interactions with Toll-like receptors and adhesion molecules. Regulation of the inflammatory response associated with commensal colonization suggests a possible role for Treg cells in controlling the upper airway responses to bacterial microflora with both bacteria-bacteria and bacteria-host interactions affecting colonization and immune responses.
主要呼吸道微生物病原体之间的动态相互作用十分复杂。对于呼吸道多种共生细菌自然获得性免疫反应影响的理解正在缓慢发展。维持微生物群落平衡以及宿主应对与疾病相关失衡的能力至关重要。对获得性免疫反应的研究发现，与单一微生物定植相比，多种细菌的存在会抑制抗体和细胞免疫反应。微生物通过一系列受体 - 配体相互作用与黏膜上皮相互作用，包括与Toll样受体和黏附分子的相互作用。与共生定植相关的炎症反应调节表明，调节性T细胞在控制上呼吸道对细菌微生物群落的反应中可能发挥作用，细菌与细菌以及细菌与宿主的相互作用都会影响定植和免疫反应。
