La Torre Giuseppe, de Waure Chiara, Chiaradia Giacomina, Mannocci Alice, Capri Stefano, Bamfi Francesco, Ricciardi Walter
Institute of Hygiene, Catholic University of the Sacred Heart-Rome, Rome, Italy.
Hum Vaccin. 2011 Sep;7(9):900-4. doi: 10.4161/hv.7.9.16084. Epub 2011 Sep 1.
The HTA is a multidisciplinary approach which is increasingly applied worldwide in order to support decision-makers in the introduction of health technologies. The application of HTA to vaccines is quite recent and linked to the increasing number of vaccines available or in development, especially to those intended to non pediatric immunization. In this article a description of the HTA approach used in the evaluation of the bivalent HPV vaccine in Italy is provided; moreover the reasons for keeping HTA process "alive" and identifying new or pending Public Health issues are discussed. In fact, the project raised questions and challenges about the standardization and sharing of HTA methods in Italy. Recently the need of updating the results is starting to be seen as urgent due to the evolution of scientific knowledge, the availability of the first results after technology introduction and the observed differences in vaccination strategies among Italian regions. Moreover in these last two years after the completion of the HTA project a number of new issues have risen in the Italian context as immunization rates, regional vaccination strategies, processes for vaccine selection and health economic issues.
卫生技术评估（HTA）是一种多学科方法，在全球范围内越来越多地被应用，以支持决策者引入卫生技术。HTA应用于疫苗领域的时间相对较近，这与可用或正在研发的疫苗数量不断增加有关，特别是那些用于非儿童免疫的疫苗。本文介绍了意大利在评估二价人乳头瘤病毒（HPV）疫苗时所采用的HTA方法；此外，还讨论了使HTA过程保持“活力”以及识别新的或悬而未决的公共卫生问题的原因。事实上，该项目引发了关于意大利HTA方法标准化和共享的问题与挑战。由于科学知识的发展、技术引入后的首批结果的可得性以及意大利各地区在疫苗接种策略上观察到的差异，最近更新结果的需求开始被视为紧迫。此外，在HTA项目完成后的过去两年里，意大利出现了一些新问题，如免疫接种率、地区疫苗接种策略、疫苗选择流程和卫生经济问题。
