Abdel-Hamid Nabil Mohie, Nazmy Maiiada Hasan, Mahmoud Ahmed Wahid, Fawzy Michael Atef, Youssof Marco
Nabil Mohie Abdel-Hamid, Maiiada Hasan Nazmy, Ahmed Wahid Mahmoud, Michael Atef Fawzy, Marco Youssof, Biochemistry Department, Unit of Liver cancer research, Faulty of Pharmacy, Minia University, Minia 002086, Egypt.
World J Hepatol. 2011 Jul 27;3(7):175-83. doi: 10.4254/wjh.v3.i7.175.
In this review we outline the different mechanisms mediating hepatocarcinogenesis. We also discuss possible targets of bioactive herbal agents at different stages of hepatocarcinogenesis and highlight their role at each individual stage. We gathered information on the most common herbal prescriptions and extracts thought to be useful in prevention or sensitization for chemotherapy in management of hepatocellular carcinoma (HCC). The value of this topic may seem questionable compared to the promise offered for HCC management by chemotherapy and radiation. However, we would recommend the use of herbal preparations not as alternatives to common chemo /and or radiotherapy, but rather for prevention among at-risk individuals, given that drug/herb interactions are still in need of extensive clarification. The bioactive constituents of various herbs seem to be promising targets for isolation, cancer activity screening and clinical evaluation. Finally, herbal preparations may offer a cost effective protective alternative to individuals known to have a high risk for HCC and possibly other cancers, through maintaining cell integrity, reversing oxidative stress and modulating different molecular pathways in preventing carcinogenesis.
在本综述中，我们概述了介导肝癌发生的不同机制。我们还讨论了生物活性草药制剂在肝癌发生不同阶段可能的作用靶点，并强调了它们在各个阶段的作用。我们收集了有关最常见的草药处方和提取物的信息，这些草药被认为对肝细胞癌（HCC）的化疗预防或增敏有用。与化疗和放疗为肝癌治疗带来的前景相比，这个主题的价值可能看起来值得怀疑。然而，鉴于药物/草药相互作用仍需大量阐明，我们建议使用草药制剂不是作为常见化疗和/或放疗的替代品，而是用于高危个体的预防。各种草药的生物活性成分似乎是分离、癌症活性筛选和临床评估的有前景的靶点。最后，草药制剂可能通过维持细胞完整性、逆转氧化应激和调节不同分子途径来预防癌变，从而为已知有高肝癌风险以及可能其他癌症风险的个体提供一种经济有效的保护选择。
